RUI:Directed Molecular Architectural Assembly via Dynamic Covalent Chemistry

美国国家科学基金会的大分子、超分子和纳米化学(MSN)计划支持曼荷莲学院的Darren Hamilton教授关于开发和利用一种新的方法来进行热力学控制的分子结构组装的工作。本研究建立在经典共轭加成化学的可行性基础上，在可逆条件下建立精心设计的整体结构的碳框架。特别是，通过这种方法可以促进具有复杂拓扑结构的有机分子-轮烷和环戊烷的形成，为获得具有潜在价值的成像和传感性能的材料开辟了一条直接的途径。在本科生唯一的女子学院芒特霍利奥克大学的这一奖项的支持下，他们致力于涵盖有机合成、结构分析和新材料性质调查的项目。重点是建立简明、廉价、模块化的方法，广泛适用于为当代问题(如传感和成像)准备材料。对美国在这些领域的竞争力的贡献来自于在该奖项的支持下进行的具体研究，以及在新兴合成和材料化学领域接受培训的新一代本科生的准备工作。与当地高中教师的合作得到了支持，目的是将研究的插图部分引入实验室教学。

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program at the National Science Foundation supports the work of Professor Darren Hamilton at Mount Holyoke College concerning the development and utilization of a new approach for the thermodynamically controlled assembly of molecular architectures. This research builds upon the viability of classic conjugate addition chemistry to establish, under reversible conditions, carbon frameworks of elaborate overall structure. In particular, the formation of topologically complex organic molecules-rotaxanes and catenanes-is facilitated via this approach, opening a straightforward route to materials with potentially valuable imaging and sensing properties.With support from this award students at Mount Holyoke, an undergraduate only women's college, work on projects that span organic synthesis, structural analysis, and investigations of the properties of new materials. A premium is placed on establishing concise, inexpensive, modular methods of broad general applicability to the preparation of materials for contemporary problems such as sensing and imaging. Contributions to US competitiveness in these fields is derived from both the specific research undertaken with support from this award, and from the preparation of new generations of undergraduates trained in emerging areas of synthetic and materials chemistry. Collaborations with local high school teachers are supported with the intention of drawing illustrative components of the research into laboratory teaching.