Asymmetric Coordination Polymerization Catalysis of Polar Vinyl Monomers

科罗拉多州立大学的Eugene Y. Chen教授在化学系化学催化项目的支持下，探索极性乙烯基单体的不对称配位聚合（ACP）催化的范围和潜力。该项目提出了四个主要目标：(1)开发同时合成手性聚合物和外消旋单体的动力学拆分聚合；(2)进一步发展催化不对称配位聚合；(3)研究手性阴离子将外消旋催化剂拆分为ACP催化剂；(4)研究了螺旋聚合物负载的手性有机催化剂的合成。将采用合成、催化、机械和计算方法来完成上述目标。从环境可持续的原材料合成具有工业重要性的聚合物为从石油化工来源获得的聚合物提供了一个有吸引力的替代品。与现有的聚合工艺相比，所提出的催化体系具有显著的优势，可用于生产重要的手性聚合物，包括从生物可再生丁内酯基单体衍生的手性聚合物。学生，包括女性和少数族裔，将在有机合成、催化和有机金属化学方面接受复杂的实验和理论方法的培训。

Professor Eugene Y. Chen of Colorado State University is supported by the Chemical Catalysis Program in the Division of Chemistry to explore the scope and potential of the asymmetric coordination polymerization (ACP) catalysis of polar vinyl monomers. The project advances four main objectives: (1) to develop kinetic resolution polymerization for the simultaneous synthesis of chiral polymers and the resolution of racemic monomers; (2) to further develop catalytic asymmetric coordination polymerization; (3) to investigate the resolution of racemic catalysts by chiral anions into ACP catalysts; and (4) to investigate the synthesis of helical polymer-supported chiral organic catalysts. Synthetic, catalytic, mechanistic, and computational methods will be employed to accomplish the above stated objectives.The synthesis of polymers of industrial importance from environmentally sustainable raw materials offers an attractive alternative to polymers derived from petrochemical sources. The proposed catalytic system offers significant advantages over existing polymerization processes for the production of important chiral polymers, including chiral polymers derived from biorenewable butyrolactone-based monomers. Students, including women and minorities, will be trained in sophisticated experimental and theoretical methodologies in organic synthesis, catalysis, and organometallic chemistry.