Natural Product Synthesis: A Context for the Study of Molecular Structure and Reactivity

在这个项目中，由化学系的化学合成计划资助，新泽西州立大学罗格斯大学化学和化学生物学系的Lawrence J.威廉姆斯教授旨在建立对不对称分子的结构和反应性的深入理解，并显着扩展不对称分子在化学合成中的战略应用。 作为该项目的一部分，由于稳定构象形成而不对称的化合物将以对映体富集的形式合成。不对称物种缺乏典型的立体中心或手性轴，很少被用作关键的战略要素。将制备合适的支架用于结构、机理和方法学研究，并将评估其进行立体选择性转化以得到具有进一步研究价值的结构复杂的天然产物的能力。更广泛的影响包括在多元化和综合的学习环境中培训本科生，研究生和博士后学生，鼓励知识和经验分享，并在更大的新泽西化学界建立联系和合作。该项目可以推进制备合成产品的专有技术。 无论是化学品、试剂、催化剂、中间体、治疗剂、聚合物还是分子工具、探针、材料或机器，合成产品的用途跨越科学和工程，渗透到现代世界。 有机化学的大部分知识都是直接或间接地从旨在合成具有挑战性的分子的研究中提取的，复杂分子合成仍然是促进我们对分子结构和反应性理解的最有效渠道。

In this project, funded by the Chemical Synthesis Program of the Chemistry Division, Professor Lawrence J. Williams of the Department of Chemistry and Chemical Biology at Rutgers, The State University of New Jersey aims to establish a deep understanding of the structure and reactivity of dissymmetric molecules and to extend significantly the strategic application of dissymmetric molecules in chemical synthesis. As part of this project, compounds that are dissymmetric due to stable conformer formation will be synthesized in enantioenriched form. Dissymmetric species lack the archetypal stereogenic center or axis of chirality and have been used as key strategic elements only very rarely. Suitable scaffolds will be prepared for structural, mechanistic, and methodology studies, and will be evaluated for their ability to undergo stereoselective transformations to give structurally complex natural products of value for further study. The broader impacts involves training undergraduate, graduate, and postdoctoral students in a diverse and integrated learning environment that encourages knowledge and experience sharing and builds ties and collaborations in the greater New Jersey chemistry community.This project could advance the knowhow to prepare synthetic products. Be they chemicals, reagents, catalysts, intermediates, therapeutics, polymers, or molecular tools, probes, materials, or machines, the uses of synthetic products span science and engineering and permeate the modern world. Much of the knowledge categorized as organic chemistry was extracted, either directly or indirectly, from studies aimed at the synthesis of challenging molecules and complex molecule synthesis continues to be the most effective conduit for advancing our understanding of molecular structure and reactivity.