State-resolved Spectroscopy and Dynamics of Chemical Transients

状态分辨光谱学和化学瞬态动力学

• 批准号: 1012685
• 负责人: David Nesbitt
• 金额: $ 53.5万
• 依托单位: University of Colorado at Boulder
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1012685&HistoricalAwards=false
• 关键词: State; resolved; Spectroscopy; Dynamics; Chemical

David Nesbitt of the University of Colorado at Boulder is supported by an award from the Chemical Structure, Dynamics and Mechanism program in the Chemistry division to study state-resolved spectroscopy and dynamics of chemical transients. The overall goals of this experimental program are threefold: i) to exploit high sensitivity direct absorption IR laser methods for study of jet-cooled radicals and fundamental molecular ions in slit supersonic discharges, ii) to augment these spectroscopic tools for quantum state-resolved collision studies at gas-ionic solution interfaces, and iii) to utilize time-resolved fluorescence microscopy methods for study of folding/unfolding kinetics at the single molecule level.Highly reactive, very-short lived molecular species are important for many processes, ranging from atmospheric chemistry at the marine boundary to chemistry in the interstellar media. Additionally, this project involves using single molecular spectroscopy to study the kinetics of folding and unfolding of RNA molecules which is important to our understanding of many biological processes. A diverse group of individuals are involved the research including women and underrepresented minorities. The PI is also the Director of the "CU Wizards" Scientific Outreach program which organizes hands-on lecture/demonstrations for elementary and middle school students.

科罗拉多大学博尔德分校的David Nesbitt获得了化学部门化学结构、动力学和机制项目的奖励，研究化学瞬态的状态分辨光谱和动力学。该实验项目的总体目标有三个方面：1)利用高灵敏度直接吸收红外激光方法来研究狭缝超音速放电中的喷气冷却自由基和基本分子离子；2)增加这些光谱工具，用于气体-离子溶液界面的量子态分辨碰撞研究；3)利用时间分辨荧光显微镜方法研究单分子水平的折叠/展开动力学。从海洋边界的大气化学到星际介质中的化学，高活性、寿命极短的分子物种对许多过程都很重要。此外，该项目涉及到使用单分子光谱来研究RNA分子折叠和展开的动力学，这对我们理解许多生物过程很重要。参与研究的个人群体多样化，包括妇女和代表性不足的少数民族。PI也是“CU奇才”科学推广计划的负责人，该计划为中小学生组织实践讲座/示范。

项目成果

Size-Dependent Photoionization in Single CdSe/ZnS Nanocrystals

单 CdSe/ZnS 纳米晶体中尺寸依赖性光电离

• DOI: 10.1021/nl402607a
• 发表时间: 2013
• 期刊: Nano Letters
• 影响因子: 10.8
• 作者: Early, Kevin T.;Nesbitt, David J.
• 通讯作者: Nesbitt, David J.

Pulsed IR Heating Studies of Single-Molecule DNA Duplex Dissociation Kinetics and Thermodynamics

• DOI: 10.1016/j.bpj.2013.11.008
• 发表时间: 2014-01-07
• 期刊: BIOPHYSICAL JOURNAL
• 影响因子: 3.4
• 作者: Holmstrom, Erik D.;Dupuis, Nicholas F.;Nesbitt, David J.
• 通讯作者: Nesbitt, David J.

High-Resolution Rovibrational Spectroscopy of Jet-Cooled Phenyl Radical: The ν 19 Out-of-Phase Symmetric CH Stretch

喷射冷却苯基自由基的高分辨率旋转振动光谱：δ 19 异相对称 CH 拉伸

• DOI: 10.1021/jp400702p
• 发表时间: 2013
• 期刊: The Journal of Physical Chemistry A
• 作者: Buckingham, Grant T.;Chang, Chih-Hsuan;Nesbitt, David J.
• 通讯作者: Nesbitt, David J.

Single-Molecule Kinetics Reveal Cation-Promoted DNA Duplex Formation Through Ordering of Single-Stranded Helices

• DOI: 10.1016/j.bpj.2013.05.061
• 发表时间: 2013-08-06
• 期刊: BIOPHYSICAL JOURNAL
• 影响因子: 3.4
• 作者: Dupuis, Nicholas F.;Holmstrom, Erik D.;Nesbitt, David J.
• 通讯作者: Nesbitt, David J.

Plasmon Mediated Multiphoton Photoemission Microscopy of Au Nanoholes and Nanohole Dimers

• DOI: 10.1021/jp411943f
• 发表时间: 2014-03
• 期刊: Journal of Physical Chemistry C
• 影响因子: 3.7
• 作者: T. Baker;A. Grubisic;D. Nesbitt