SBIR Phase I: Rydberg Fingerprint Spectroscopy for Sensitive Identification of Isomerically-Dependent Environmental Pollutants. Test Case: Dioxins

SBIR 第一阶段：里德伯指纹光谱用于灵敏识别异构相关环境污染物。

• 批准号: 1013149
• 负责人: Joseph Geiser
• 金额: $ 14.98万
• 依托单位: Ryon Technologies Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1013149&HistoricalAwards=false
• 关键词: SBIR; Phase; Rydberg; Fingerprint; Spectroscopy

This SBIR Phase I project will develop a spectroscopic device for detecting and discriminating congeners of isomeric compounds based on their Rydberg spectroscopic "fingerprints." It enables the development of a newanalytical tool for the detection of dioxins which are environmental contaminants that arise from combustion of organic materials in the presence of chlorine. Dioxins build up in human tissues, causing long-term health problems including cancer, diabetes, endometriosis and others. The toxicity of many isomers is unknown, as it is difficult to selectively identify many isomeric forms of dioxins. Current analytical methods involve mass spectrometry (MS), or tandem-MS techniques. However, the former cannot identify individual isomers, while the latter lacks sufficient sensitivity to reach low detection limits. The broader/commercial impact of the project will be to potentially impact the $6 billion worldwide market for mass spectrometers, of which the investigators expect to capture 1 percent, or $60 million. In addition, differentiation of isomeric forms with high sensitivity in a compact form-factor would be a new and welcome capability in multiple scientific fields, including air pollution monitoring, toxicology, and exposure assessment.

这个SBIR第一阶段项目将开发一种光谱设备，用于根据同分异构体的里德堡光谱“指纹”来检测和区分它们的同系物。它使得能够开发一种新的分析工具来检测二恶英，二恶英是有机材料在氯存在下燃烧产生的环境污染物。二恶英在人体组织中积聚，导致癌症、糖尿病、子宫内膜异位症等长期健康问题。许多异构体的毒性尚不清楚，因为很难选择性地识别二恶英的许多异构体。目前的分析方法包括质谱仪(MS)，或串联质谱仪技术。然而，前者不能识别单个异构体，而后者缺乏足够的灵敏度来达到低检测限。该项目的更广泛/商业影响将是潜在地影响全球60亿美元的质谱仪市场，调查人员预计将获得1%的市场份额，即6000万美元。此外，在紧凑的外形因素中区分具有高灵敏度的异构体将是包括空气污染监测、毒理学和暴露评估在内的多个科学领域的一项新的受欢迎的能力。