SBIR Phase I: System for creation and use of realistic cardiac electromechanical simulation models

这个小型企业创新研究(SBIR)第一阶段项目将探索用户友好的跨平台计算系统的开发和商业可行性，该系统用于多尺度组织和器官的心脏电生理学和机电建模。具体的技术目标包括：1)评估组装自动化管道的技术可行性；2)评估开发集心脏机电模型组装、仿真和分析为一体的跨平台图形用户界面(GUI)的技术可行性；以及3)测试和改进原型系统以满足客户需求，并利用用户输入来评估系统的商业可行性。拟议的系统将使发现和开发诊断和治疗心脏病的新方法成为可能，并允许虚拟探索从蛋白质到整个器官的心律紊乱和机电功能障碍的机制。该系统将包括直接输入心脏成像数据的能力。用户将能够定制系统的各个组件的行为，以表示特定的心脏病理、目标和干预措施。模拟将易于管理，强大的跨平台用户友好界面将使结果毫不费力地可视化。该项目更广泛的影响/商业潜力源于这样一个事实，即他提议的系统代表了心脏机电模拟方法的巨大范式转变。它不仅将使用有史以来开发的最复杂的心脏模拟工具在一个易于使用的系统中集成心脏的电气和机械功能，而且打算使社会的各个方面都能进行模拟。目前，心脏模型仅在少数几个学术实验室用于探索心脏病诊断和治疗的新方法。然而，心脏设备制造、生物技术和制药行业对心脏组织和器官建模有着浓厚的兴趣。对于设备公司来说，这提供了一个开发和测试原型设备和治疗模式的机会。对于制药公司来说，它提供了一个无与伦比的机会，可以快速筛选药物的致心律失常效果。它还为学术研究人员提供了好处，因为复杂的最先进的模拟工具将开辟新的研究视野，特别是个性化医学中的转化性研究项目。最后，该系统有望成为一种有效的教学工具，成为生物医学和临床课程的一部分。

This Small Business Innovation Research (SBIR) Phase I project will explore the development and commercial feasibility of a user-friendly cross-platform computing system for multi-scale tissue and organ cardiac electrophysiology and electromechanics modeling. Specific technical objectives include: 1) Assessing the technical feasibility of assembling an automated pipeline; 2) Assessing the technical feasibility of developing a cross-platform graphic user interface (GUI) that integrates cardiac electromechanical model assembly, simulation, and analysis; and 3) Testing and refining the prototype system to meet customer needs and utilizing user input to assess the commercial feasibility of the system. The proposed system will enable the discovery and development of new approaches to the diagnosis and treatment of cardiac disease and allow virtual exploration of mechanisms of cardiac rhythm disorder and electromechanical dysfunction, from the protein to the entire organ. The system will include capabilities for direct input of cardiac imaging data. Users will be able to tailor the behavior of individual components of the system to represent specific cardiac pathologies, targets, and interventions. Simulations will be managed with ease,and a robust cross-platform user-friendly interface will allow effortless visualization of results.The broader impact/commercial potential of this project stems from the fact that he proposed system represents an enormous paradigm shift in the way cardiac electromechanical simulation is done. It will not only integrate, in one easy-to-use system, cardiac electrical and mechanical function using the most sophisticated cardiac simulation tools ever developed, but intends to make simulation accessible to a very broad aspect of society. Currently, cardiac modeling is used in the exploration of new approaches to the diagnosis and treatment of cardiac disease only in a few academic laboratories. However, cardiac device manufacturing, biotech, and pharmaceutical industries have a significant interest in cardiac tissue and organ modeling. For device companies, it presents an opportunity to develop and test prototype devices and treatment modalities. For pharmaceutical companies, it offers an unrivaled opportunity to quickly screen drugs for proarrhythmic effects. It also provides benefits to academic researchers since sophisticated state-of-the-art simulation tools will open new research horizons, particularly translational research projects in personalized medicine. Finally, the proposed system is expected to become an effective teaching tool, and part of biomedical and clinical curricula.