Conference - FASEB meeting on Post-transcriptional Control of Gene Expression: Mechanisms of mRNA Decay to be held July 11-16, 2010 in Carefree, AZ

学术价值：FASEB会议？基因表达的转录后调控：mRNA衰变的机制？将于2010年7月11日至16日在亚利桑那州无忧无虑举行。 信使RNA周转是基因表达的关键调节因子。mRNA的稳定性显著地决定了其稳态积累，并且可以通过细胞内和细胞外环境因子来调节，以提供对调节信号的快速响应机制。mRNA的程序稳定性或不稳定性可以分别增强或抑制基因表达。 此外，多种监视途径利用mRNA周转来维持mRNA质量，并确保只有适当加工的转录物离开细胞核并被翻译机制用作底物。 此外，非编码RNA和RNA干扰最近吸引了生命科学所有领域的相当大的兴趣，因为它们依赖于选择性mRNA周转来实现其对基因沉默的生物学后果。这次会议已经发展成为一个独特的会议，汇集了真核生物，古细菌和原核系统的领先mRNA周转专家到一个竞技场，并为mRNA周转的广泛学科的研究人员提供了一个互动，交流思想和产生未来研究新领域的机会。我们预计，本次会议将提供一个突出的概述，目前和未来的方向，这一令人兴奋的领域，为既定的调查人员和学员，因为他们有助于推动该领域的下一个层次的发展。更广泛的影响：会议的更广泛的影响包括机会，以促进初级调查人员的发展。 会议的形式旨在促进所有参与者之间的最大科学互动，并确保学生和博士后同事能够与mRNA周转领域的领导者会面并讨论他们的研究和未来计划。 所有参与者都有机会展示他们研究的海报。 此外，每次平台会议将包括从提交的海报摘要中选出的年轻科学家至少一次口头介绍，以使年轻科学家获得最大程度的接触。

Intellectual merit: The FASEB Conference on ?Posttranscriptional control of gene expression: mechanisms of mRNA decay? will be held in Carefree, AZ on July 11-16, 2010. Messenger RNA turnover is a critical regulator of gene expression. The stability of an mRNA significantly dictates its steady-state accumulation and can be modulated by both intracellular and extracellular environmental factors to provide a rapid response mechanism to regulatory signals. Programmed stability or instability of mRNAs can enhance or repress gene expression, respectively. Moreover, multiple surveillance pathways utilize mRNA turnover to maintain mRNA quality and ensure only properly processed transcripts exit the nucleus and are utilized as substrates by the translation machinery. In addition, noncoding RNAs and RNA interference have recently attracting considerable interest from all areas of the life sciences, since they rely on selective mRNA turnover for their biological consequence on gene silencing. This meeting has developed into a unique conference that brings together the leading mRNA turnover experts in eukaryotic, archaebacteria and prokaryotic systems into one arena and provides an opportunity for researchers in the broad discipline of mRNA turnover to interact, exchange ideas and spawn new areas of future research. We anticipate this conference will provide an outstanding overview of the current and future direction of this exciting field for established investigators and trainees as they help propel the field to the next level of its development.Broader impacts: The broader impact of the conference includes the opportunity to foster the development of junior investigators. The format of the conference is designed to promote maximal scientific interactions among all the participants and ensure students and postdoctoral associates will be able to meet and discuss their research and future plans with leaders in the mRNA turnover field. All participants have an opportunity to present posters on their research. In addition, each platform session will contain at least one oral presentation by junior scientists selected from the submitted poster abstracts to provide maximal exposure for young scientists.