FASEB Summer Research Conference, Lung Surfactant: Molecular and Cell Biology

描述（由申请人提供）： 本次会议的总体目标是提供一个论坛，交流有关胎肺发育和表面活性剂产生细胞分化的基本分子和细胞生物学，表面活性剂脂质和蛋白质合成，运输和分泌调节机制的新的和前沿信息。会议还将强调表面活性剂系统的病理生理学，关于蛋白质错误折叠和疾病，肺损伤和修复。我们相信这次会议是独一无二的，非常重要，因为除了邀请表面活性剂领域公认的专家发言外，我们还邀请了在不同但相关领域工作的知名专家，以提供有关干细胞生物学和器官发生，蛋白质错误折叠，细胞器生物发生和贩运以及宿主防御等主题的深入信息。 所涉及的具体主题包括： 1.肺发育的遗传控制 2.人肺疾病中表面活性蛋白结构改变导致的细胞器生物发生和病理生理学。 3.肺上皮可塑性、再生和修复的调节。 4.与肺表面活性蛋白突变异常肺发育相关的人类肺部疾病的分子发病机制。 5.凝集素与粘膜宿主防御。 6.新型表面活性剂治疗剂的设计。

DESCRIPTION (provided by applicant): The overall objective of this conference is to provide a forum for the exchange of new and cutting-edge information regarding the basic molecular and cellular biology of fetal lung development and differentiation of surfactant producing cells, mechanisms in the regulation of synthesis, trafficking and secretion of surfactant lipids and proteins. The conference also will emphasize the pathophysiology of the surfactant system, with regard to protein misfolding and disease, lung injury and repair. We believe that this meeting is unique and highly important, because in addition to inviting speakers who are recognized experts in the surfactant field, we have included renowned experts working in different but related areas to provide in-depth information on topics of stem cell biology and organogenesis, protein misfolding, organelle biogenesis and trafficking and host defense. The specific topics covered include: 1. Genetic control of lung development 2. Organelle biogenesis and the pathophysiology that results from structural alterations of surfactant proteins in human lung diseases. 3. Regulation of lung epithelial plasticity, regeneration, and repair. 4. Molecular pathogenesis of human lung diseases associated with abnormal lung development of mutations in the surfactant proteins. 5. Collectins and mucosal host defense. 6. Design of novel surfactant-based therapeutics.