RUI: Genomic architecture of adaptive radiation: a role for gene duplication among African cichlid radiations

RUI：适应性辐射的基因组结构：非洲慈鲷辐射中基因复制的作用

• 批准号: 1021582
• 负责人: Susan Renn
• 金额: $ 30.83万
• 依托单位: Reed College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1021582&HistoricalAwards=false
• 关键词: RUI; Genomic; architecture; adaptive; radiation

Gene duplication and the subsequent evolution of the duplicates is an important source of genetic and functional novelty in all three domains of life. As the African cichlid fishes have undergone rapid, recent and repeated speciation events, they constitute an ideal model with which to test long-standing hypotheses about the role of gene duplication in evolutionary expansion, speciation and adaptation to the environment. This project will employ modern genomic techniques using genomic hybridization to identify duplicated genes. Gene duplicate number, gene duplication rate and retention of gene duplicates from specific functional categories will be investigated for an association with enhanced speciation as well as ecological diversification. Sequence analysis of duplicated genes across this group of fishes will address the degree to which natural selection is responsible for the evolution of gene duplicates.In addition to the significant contribution to genomic resources for the cichlid research community, this project also advances a broad range of studies concerning the evolution of duplicated genes and their contribution to diversity and adaptation. The project, conducted at Reed College, will strengthen the genomics/bioinformatics program, capitalizing upon the PIs interdisciplinary collaborations. The cutting edge techniques and manipulation of large datasets will provide a rigorous training through the formation of an interdisciplinary research team involving undergraduate students of mathematics and biology. Furthermore, the research will be directly linked with the PIs teaching in Comparative Functional Genomics and will be incorporated into outreach teaching modules on animal diversity and genome evolution.

基因复制和复制品的后续进化是生命所有三个领域中遗传和功能新奇的重要来源。由于非洲慈鲷鱼经历了快速，最近和重复的物种形成事件，它们构成了一个理想的模型，以测试长期存在的假设基因复制的进化扩张，物种形成和适应环境的作用。这个项目将采用现代基因组技术，利用基因组杂交来识别重复的基因。将研究基因重复数、基因重复率和特定功能类别的基因重复保留与物种形成和生态多样化的关系。重复基因的序列分析在这组鱼类将地址的程度，自然选择是负责基因重复的进化。除了为慈鲷研究界的基因组资源的重大贡献，该项目还推进了广泛的研究有关重复基因的进化及其对多样性和适应性的贡献。该项目在里德学院进行，将加强基因组学/生物信息学计划，利用PI的跨学科合作。尖端技术和大型数据集的操作将通过组建一个涉及数学和生物学本科生的跨学科研究团队提供严格的培训。此外，该研究将与比较功能基因组学的PI教学直接联系，并将纳入动物多样性和基因组进化的外展教学模块。