Multiscale Study on Biomechanical Roles of Soft Tissue on Bone Remodelling

软组织对骨重塑的生物力学作用的多尺度研究

• 批准号: DP160104602
• 负责人: Prof Qing Li
• 金额: $ 25.22万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-08-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160104602
• 关键词: Multiscale; Study; Biomechanical; Roles; Soft

The project aims to increase our knowledge of the processes of bone remodelling and the role of soft tissue in this process. Mechanical force is a key stimulus for regulating bone remodelling. A significant question in biomechanics is why orthodontics only use very small forces (1 Newton) to generate significant oral bone remodelling, whereas prosthodontics that apply three orders of magnitude higher forces (~1000 Newton) do not move dental implants. This project aims to develop new multiscale modelling and remodelling techniques in computational mechanics to explore the roles played by connective soft tissue in bone adaptation. Expected project outcomes would increase our understanding in biomechanics and affect health care disciplines such as orthodontics, prosthodontics and orthopaedics.

该项目旨在增加我们对骨重建过程和软组织在此过程中的作用的了解。机械力是调节骨重建的关键刺激。生物力学中的一个重要问题是，为什么正畸学只使用非常小的力（1牛顿）来产生显著的口腔骨重塑，而应用三个数量级更高的力（~1000牛顿）的修复学不会移动牙科植入物。该项目旨在开发计算力学中的新的多尺度建模和重塑技术，以探索结缔软组织在骨适应中所扮演的角色。预期的项目成果将增加我们对生物力学的理解，并影响医疗保健学科，如整形外科，口腔修复学和矫形外科。