Doctoral Dissertation Improvement: The Impact of Globalization and Psychosocial Stress on Gestation Length and Pregnancy Outcomes on the Pacific Island of Tutuila

博士论文改进：全球化和社会心理压力对太平洋图图伊拉岛妊娠长度和妊娠结果的影响

• 批准号: 1028966
• 负责人: Darna Dufour
• 金额: $ 2万
• 依托单位: University of Colorado at Boulder
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1028966&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Improvement; Impact; Globalization

Short-term, retrospective, cross-sectional studies set in western countries have discovered a pattern of pregnancy disruption associated with stressful events. Incidences of spontaneous abortions, stillbirths, low birth weights and premature delivery have all been quantitatively associated with increased maternal stress. Little is known, however, about how disparities in the social status of non-western women can impact pregnancy outcomes and resultant infant health. The objective of the proposed research is to determine the association of social status and chronic psychosocial stress on spontaneous abortion, gestation length and neonate body size. This longitudinal, prospective, biocultural study measures psychosocial stress in women prior to conception, through pregnancy and concludes with a postpartum follow-up on the health of their infants. Early pregnancy loss will be determined using fertility monitors and urine based pregnancy tests. Two interrelated indicators of psychosocial stress, Epstein-Barr virus (EBV) antibody concentration and status incongruence, will be used to assess the effects of stress on pregnancy outcomes of 108 women on the American Samoan island of Tutuila. Fingertip dried blood spots are collected from mothers prior to and throughout the course of their pregnancy and analyzed for EBV and C-reaction protein levels (CRP). CRP levels detect infection and are then used to control EBV levels. Combined with interviews and maternal and infant anthropometrics, these techniques make it possible to identify the impact of psychosocial stress on all stages of pregnancy and to assess the role of maternal stress on health outcomes of infants. These data provide an opportunity to assess pregnancy outcomes in terms of psychosocial stress over the course of gestation and information regarding a specific type of psychosocial stress on pregnancy. Data from this study provides insight into pregnancy loss, the least well understood component of reproduction. Additionally, the co-PI is participating in community outreach and education programs for girls and women in Tutuilla.

在西方国家进行的短期、回顾性、横断面研究发现了一种与压力事件相关的妊娠中断模式。自然流产、死产、出生体重不足和早产的发生率在数量上都与产妇压力增加有关。然而，人们对非西方妇女社会地位的差异如何影响怀孕结果和婴儿健康知之甚少。本研究的目的是探讨社会地位和慢性心理社会压力对自然流产、妊娠期长短和新生儿体型的影响。这项纵向的、前瞻性的、生物文化的研究测量了妇女在怀孕前、怀孕期间的心理社会压力，并以产后对婴儿健康的随访为结论。将使用生育监测仪和基于尿液的妊娠试验确定早期妊娠丢失。两个相互关联的指标的心理社会压力，EB病毒（EBV）抗体浓度和状态不一致，将被用来评估压力对妊娠结局的108名妇女在美属萨摩亚的图图伊拉岛。在怀孕前和整个怀孕过程中从母亲收集指尖干燥的血点，并分析EBV和C反应蛋白（CRP）水平。CRP水平检测感染，然后用于控制EBV水平。这些技术与访谈和母婴人体测量相结合，可以确定心理社会压力对怀孕各个阶段的影响，并评估产妇压力对婴儿健康结果的作用。这些数据提供了一个机会，以评估怀孕过程中的心理社会压力方面的怀孕结果和有关怀孕的特定类型的心理社会压力的信息。这项研究的数据提供了对妊娠丢失的深入了解，这是生殖过程中最不了解的部分。 此外，共同主要负责人还参加了针对图图伊拉女孩和妇女的社区外联和教育方案。