Dexterous Fiber Optic Tweezers for Bio-Particle Manipulation and Force Sensing

1031331苗族大学马里兰大学本研究项目的目标是开发一种灵巧的双纤维镊子系统，使其具有极大的灵活性、功能性和效率。通过这项研究，将通过深入的分析、数值和实验研究相结合，实现对这种微/纳米颗粒操纵和传感系统的基本了解。与传统的光纤镊子相比，采用表面等离子体透镜的新型光纤镊子将显著提高捕获效率。此外，通过利用先进的光纤调制技术，新型光纤镊子将能够实现高速、高分辨率的动态俘获位置控制。预计这一努力不仅将丰富传感器、致动器和生物光子学领域，还将为开发生物系统研究的创新工具铺平道路，并进一步阐明病理机制和疾病诊断。本科生和研究生的学习经验将通过跨学科课程得到丰富。通过让K-12学生参与马里兰大学的多学科研究活动，将激发他们对科学和工程的兴趣。将通过科学和工程少数群体中心的教育活动，扩大代表不足群体的参与。

Abstract1031331Miao YuUniversity of MarylandThe objective of this research project is to develop a dexterous dual fiber tweezers system with greatly enhanced flexibility, functionality, and efficiency. Through this research a fundamental understanding of such a system for manipulation and sensing of micro/nano sized particles will be achieved through a combination of thorough analytical, numerical, and experimental studies. The novel fiber optical tweezers equipped with surface plasmonic lens will significantly enhance the trapping efficiency compared with conventional fiber tweezers. Furthermore, by taking advantage of the advanced fiber optic modulation techniques, high speed and high resolution dynamical trapping position control will be enabled in the novel fiber optical tweezers. This effort is expected to not only enrich the fields of sensors, actuators, and biophotonics, but also pave the way for developing innovative tools for the study of biological systems, and shed further light on pathological mechanisms and disease diagnosis.The learning experience of undergraduate and graduate students will be enriched through an inter-disciplinary curriculum. The interests of K-12 students in science and engineering will be stimulated by involving them in multi-disciplinary research activities at the University of Maryland. Participation of underrepresented groups will be broadened through educational activities in the Center for Minorities in Science and Engineering.