Dexterous Fiber Optic Tweezers for Bio-Particle Manipulation and Force Sensing

用于生物粒子操纵和力传感的灵巧光纤镊子

• 批准号: 1031331
• 负责人: Miao Yu
• 金额: $ 20万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1031331&HistoricalAwards=false
• 关键词: Dexterous; Fiber; Optic; Tweezers; Bio

Abstract1031331Miao YuUniversity of MarylandThe objective of this research project is to develop a dexterous dual fiber tweezers system with greatly enhanced flexibility, functionality, and efficiency. Through this research a fundamental understanding of such a system for manipulation and sensing of micro/nano sized particles will be achieved through a combination of thorough analytical, numerical, and experimental studies. The novel fiber optical tweezers equipped with surface plasmonic lens will significantly enhance the trapping efficiency compared with conventional fiber tweezers. Furthermore, by taking advantage of the advanced fiber optic modulation techniques, high speed and high resolution dynamical trapping position control will be enabled in the novel fiber optical tweezers. This effort is expected to not only enrich the fields of sensors, actuators, and biophotonics, but also pave the way for developing innovative tools for the study of biological systems, and shed further light on pathological mechanisms and disease diagnosis.The learning experience of undergraduate and graduate students will be enriched through an inter-disciplinary curriculum. The interests of K-12 students in science and engineering will be stimulated by involving them in multi-disciplinary research activities at the University of Maryland. Participation of underrepresented groups will be broadened through educational activities in the Center for Minorities in Science and Engineering.

摘要1031331Miao Yuuniversity该研究项目的目的是开发灵活的双光纤镊子系统，其灵活性，功能和效率大大提高。通过这项研究，将通过彻底的分析，数值和实验研究的结合来实现对这种操纵和感知微/纳米尺寸颗粒系统的基本理解。与常规的纤维镊子相比，配备表面等离子体透镜的新型光纤光纤镊子将显着提高捕获效率。此外，通过利用高级光纤调制技术，将在新型的光纤镊子中启用高速和高分辨率动力学陷阱位置控制。预计这种努力不仅将丰富传感器，执行器和生物素化学领域，而且还可以为开发生物系统研究的创新工具铺平道路，并进一步了解病理机制和疾病诊断。 K-12学生对科学和工程的兴趣将通过使他们参与马里兰大学的多学科研究活动来激发他们的兴趣。代表性不足的群体的参与将通过科学与工程少数民族中心的教育活动来扩展。