Workshop: Nanomaterials for Shaping Immunity and Monitoring The Immune Response

1037883Fahmy智慧功绩。该提案要求支持题为：免疫治疗和免疫诊断中的纳米技术的讲习班。研讨会将在耶鲁大学举办，或与生物医学工程学会(BMES)2011年或2012年的年会一起举办。这个研讨会的目标受众将包括从化学家、材料科学家和工程师到免疫学家和内科医生的各种人才。将涵盖的领域包括免疫疗法、疫苗、纳米材料的毒理学影响、传感器以及用于检测体外和活体免疫反应的成像应用。人们对免疫在健康和疾病中的作用已知很多，但这种理解与治疗传递和诊断的工程技术相结合还缺乏。主办方实验室致力于开发和应用新型生物材料，用于检测免疫系统细胞和调节免疫。我们认为，这是一个重要的新研究方向，因为材料科学和工程学的新发展可能为有效的治疗和/或诊断铺平道路，从而绕过传统策略的并发症和局限性。这就迫切需要跨学科的翻译和交流。在这个连接免疫学和材料科学的关键接口领域取得重大进展，需要多学科的互动和新的方法，并结合交流的途径，这是本次研讨会的主题。研讨会将突出利用多种人才的努力，重点解决修复免疫缺陷、恢复免疫能力和监测免疫反应进展的问题。被邀请的演讲者将从世界各地成功解决免疫治疗和免疫监测的工程方法的团体中挑选出来。历史上最成功的医疗干预措施之一是预防性干预(疫苗接种)，它涉及合成材料佐剂和疾病相关抗原的组合。材料科学和免疫学的这种偶然结合导致了天花和脊髓灰质炎这两种最严重的全球传染病的根除。相比之下，涉及免疫系统失调的许多其他疾病状态的治疗方法开发得很差，或者根本就没有。这次研讨会将聚焦于一个因其在健康和疾病中的重要性而备受关注的变革性话题：纳米材料干预免疫的形成和检测。在纳米技术领域以及与之平行的免疫学领域已经有了很大的进步，但目前在这两个领域的社会利益的交叉方面取得了渐进的进展。这种发展减弱的一个原因是缺乏沟通和合作。第二个原因是缺乏对纳米技术在免疫学中的协同应用的认识，以及如何利用免疫学知识来创造安全的纳米材料，用于新的有效疫苗，并提高癌症和自身免疫性疾病的免疫反应。这次研讨会将鼓励新的合作，其中纳米材料开发方面将以协同的方式与免疫相联系，以开发新的治疗和诊断方法。不同的发言者，包括妇女和代表不足的少数群体，将作为发言者、小组成员和组织者参加。研讨会将向包括学术人员、学生和博士后以及工业研究人员在内的多学科研究人员小组展示和挑战纳米技术在塑造和跟踪免疫方面的应用。此外，一个专家小组将讨论促进互动的机制和对这一新研究领域的支持。

1037883FahmyIntellectual Merit. The proposal requests support for a workshop entitled: Nanotechnology in Immunotherapy and Immunodiagnostics. The workshop will be either organized at Yale University or in conjunction with the Biomedical Engineering Society (BMES) annual meeting in 2011 or 2012. The targeted audience for this workshop will include a diversity of talent ranging from chemists, material scientists, and engineers to immunologists and physicians. Areas to be covered include, immunotherapy, vaccines, toxicological impact of nanomaterials, sensors and imaging applications for detection of immune responses in vitro and in vivo.Much is known about immunity in health and disease, yet integration of this understanding with engineering technology for therapeutics delivery and diagnostics is lacking. The organizers laboratories are committed to the development and application of novel biomaterials for detection of immune system cells and modulation of immunity. We feel that that this is an important new line of investigation since new developments in materials science and engineering may pave the way for effective therapeutics and/or diagnostics that circumvent complications and limitations of conventional strategies. This necessitates an urgent need for interdisciplinary translation and communication. Major advances in this critical interface area that bridges immunology with materials science necessitates multidisciplinary interaction and new approaches combined with an avenue for communication which is the subject of this workshop. The workshop will highlight efforts to leverage multiple talents and focus to address the issue of fixing immune defects, restoring immune competence and monitoring of the progress of the immune response. Invited speakers will be chosen from groups worldwide that have been successful in addressing an engineering approach to immunotherapy and immunomonitoring.Broader Impacts. One of the most successful medical interventions in history is prophylactic intervention (vaccination), which involves the combination of synthetic material adjuvants and disease-associated antigens. This fortuitous marriage of material science and immunology led to the elimination of small pox and polio, two of the worst global infectious diseases. By contrast, therapies for many other disease states involving immune system dysregulation are poorly developed or simply unavailable. This workshop will focus on a transformative topic that is gaining great attention because of its importance in health and disease: nanomaterial intervention in shaping and detection of immunity. There has been much progress in the areas of nanotechnology, and on a parallel path, immunology, but currently there have been incremental advances in the crosstalk of both fields for societal benefits. One reason for this attenuated development is lack of communication and collaboration. A second reason is simply lack of appreciation of the synergistic applications of nanotechnology in immunology and how immunological understandings can be harnessed to create safe nanomaterials for new effective vaccines and boosting immune responses in cancer and autoimmune disease. This workshop will encourage new collaborations in which the nanomaterial development aspect will be linked in a synergistic way with immunity for development of new therapeutics and diagnostics. A diverse set of speakers, including women and underrepresented minorities will participate as speakers, panelists and organizers. The workshop will expose and challenge a multidisciplinary group of researchers, including academic faculty, students and postdocs and industrial researchers to the applications of nanotechnology in shaping and tracking immunity. Additionally, a panel of experts will discuss mechanisms for fostering interactions and support for this new area of research.