MRI: Acquisition of a CCD Single Crystal X-ray Diffraction System for Teaching and Research Among a Partnership of Central New England Institutions

来自基恩州立大学的Jerry Jasinski教授将获得一台配备CCD探测器的单晶x射线衍射仪。衍射仪将具有单晶和粉末的能力，并且可以在不同的温度下进行测量。该提案旨在加强各级的研究培训和教育，特别是在药物相关分子的结构表征，抗癌和抗炎化合物，治疗剂，模型酶复合物，肽模拟化合物，放射性药物螯合剂分子，分子磁性材料以及有机金属和无机化合物等研究领域。x射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于邻近分子的空间排列的准确信息。这里描述的研究将影响许多领域，包括有机和无机化学，材料化学和生物化学。该仪器将成为一系列新英格兰中部机构的教学和研究的组成部分，包括基恩州立大学、达特茅斯学院、新罕布什尔大学、圣安瑟姆学院、米德尔伯里学院、威廉姆斯学院和克拉克大学。

With this award from the Major Research Instrumentation (MRI) program Professor Jerry Jasinski from Keene State College will acquire a single-crystal X-ray diffractometer equipped with a CCD detector. The diffractometer would have single crystal and powder capabilities and measurements could be done at various temperatures. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as structural characterization of pharmaceutically related molecules, anticancer and anti-inflammatory compounds, therapeutic agents, model enzyme complexes, peptide mimic compounds, radiopharmaceutical chelator molecules, molecular magnetic materials and organometallic and inorganic compounds.An X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact a number of areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research in a series of Central New England Institutions that include Keene State University, Dartmouth College, University of New Hampshire, Saint Anselm College, Middlebury College, Williams College and Clark University.