MRI: Acquisition of a CCD Single Crystal X-ray Diffraction System for Teaching and Research Among a Partnership of Central New England Institutions

MRI：与新英格兰中部机构合作购买用于教学和研究的 CCD 单晶 X 射线衍射系统

• 批准号: 1039027
• 负责人: Jerry Jasinski
• 金额: $ 29万
• 依托单位: Keene State College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1039027&HistoricalAwards=false
• 关键词: MRI; Acquisition; CCD; Single; Crystal

With this award from the Major Research Instrumentation (MRI) program Professor Jerry Jasinski from Keene State College will acquire a single-crystal X-ray diffractometer equipped with a CCD detector. The diffractometer would have single crystal and powder capabilities and measurements could be done at various temperatures. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as structural characterization of pharmaceutically related molecules, anticancer and anti-inflammatory compounds, therapeutic agents, model enzyme complexes, peptide mimic compounds, radiopharmaceutical chelator molecules, molecular magnetic materials and organometallic and inorganic compounds.An X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The studies described here will impact a number of areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument will be an integral part of teaching as well as research in a series of Central New England Institutions that include Keene State University, Dartmouth College, University of New Hampshire, Saint Anselm College, Middlebury College, Williams College and Clark University.

有了这项来自主要研究仪器（MRI）计划的奖项，基恩州立学院的Jerry Jasinski教授将获得一台配备CCD探测器的单晶X射线衍射仪。衍射仪将具有单晶和粉末能力，并且可以在各种温度下进行测量。该提案旨在加强各级研究培训和教育，特别是在研究领域，如药物相关分子的结构表征，抗癌和抗炎化合物，治疗剂，模型酶复合物，肽模拟化合物，放射性药物螯合剂分子，分子磁性材料和有机金属及无机化合物。射线衍射仪允许准确和精确地测量分子的完整三维结构，包括键距和角度，并提供关于分子相对于相邻分子的空间排列的准确信息。这里描述的研究将影响许多领域，包括有机和无机化学，材料化学和生物化学。该仪器将成为一系列中央新英格兰机构的教学和研究的组成部分，这些机构包括基恩州立大学、达特茅斯学院、新罕布什尔州大学、圣安瑟姆学院、米德尔伯里学院、威廉姆斯学院和克拉克大学。