MRI: Acquisition of Nikon A1RSi Confocal Microscope with Hybrid Scanner, Spectral Unmixing and FLIM/FCS

MRI：购买带有混合扫描仪、光谱分离和 FLIM/FCS 的 Nikon A1RSi 共焦显微镜

• 批准号: 1039423
• 负责人: Sharon Bickel
• 金额: $ 63.52万
• 依托单位: Dartmouth College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1039423&HistoricalAwards=false
• 关键词: MRI; Acquisition; Nikon; A1RSi; Confocal

This Major Research Instrumentation award to Dartmouth College funds the acquisition of a confocal microscope with a hybrid scanner, spectral unmixing and components that allow for Fluorescence Lifetime Imaging (FLIM) and Fluorescence Correlation Spectroscopy (FCS) measurements. This system will significantly advance basic science research and teaching infrastructure at Dartmouth and throughout New Hampshire and Vermont. The research enabled by the new system addresses fundamental questions in cell biology and developmental biology, and utilizes a diverse array of model systems (bacteria, fungi, algae, plants, worms, flies and mice). In all cases, the new confocal system will substantially improve and expand the imaging capabilities and allow Dartmouth investigators to continue to conduct leading-edge research and to train the next generation of life scientists. Each of the faculty using the new microscope is committed to teaching science at all levels and to preparing successful future scientists and science teachers. The new system makes state-of-the-art imaging technology more accessible to undergraduate students, graduate students and post-doctoral scholars, as well as students and teachers in our local secondary schools. Furthermore, Dartmouth faculty members have an extensive history of including undergraduate interns in their research programs and incorporating the latest scientific approaches and data into their courses. The results of these research and teaching efforts will be broadly disseminated through abstracts and peer reviewed publications, as well as by active participation of students and faculty at professional meetings.

达特茅斯学院获得的这项重大研究仪器奖资助购买一台共焦显微镜，该显微镜配有混合扫描仪、光谱分解和允许荧光寿命成像 (FLIM) 和荧光相关光谱 (FCS) 测量的组件。该系统将显着推进达特茅斯以及整个新罕布什尔州和佛蒙特州的基础科学研究和教学基础设施。 新系统支持的研究解决了细胞生物学和发育生物学的基本问题，并利用了多种模型系统（细菌、真菌、藻类、植物、蠕虫、苍蝇和小鼠）。在所有情况下，新的共焦系统都将大大提高和扩展成像能力，并使达特茅斯研究人员能够继续进行前沿研究并培训下一代生命科学家。 使用新显微镜的每位教师都致力于各个级别的科学教学，并培养未来成功的科学家和科学教师。新系统使本科生、研究生和博士后学者以及当地中学的学生和教师更容易获得最先进的成像技术。 此外，达特茅斯学院的教职员工在将本科生实习生纳入其研究项目并将最新的科学方法和数据纳入其课程中方面有着悠久的历史。 这些研究和教学工作的成果将通过摘要和同行评审出版物以及学生和教师积极参与专业会议来广泛传播。