MRI: Acquisition of a Zeta Potential and Submicron Particle Size Analyzer to Enhance Research and Teaching at the University of Michigan-Dearborn

MRI：购买 Zeta 电位和亚微米粒度分析仪以加强密歇根大学迪尔伯恩分校的研究和教学

• 批准号: 1039817
• 负责人: Krisanu Bandyopadhyay
• 金额: $ 9.48万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2012-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1039817&HistoricalAwards=false
• 关键词: MRI; Acquisition; Zeta; Potential; Submicron

Technical Summary: Zeta potential and submicron particle size measurement is an integral part of the emerging interdisciplinary areas of nanotechnology and nanobiotechnology owing to its unique capability of measuring size and surface charge of nanomaterials present in the chemical and biological systems. The present instrument will offer a full range of measurement capabilities ideal for research areas ranging from material science to evolutionary biology. It is also capable of measuring Zeta potential of solid surface in solution which will be beneficial for research projects related to nanoparticles or graphene assembly on the surface. In addition, the possible size measurement range of particles in solution will facilitate its application in the research involving nanoparticles, nanoshells and even spider sperm suspensions in dilute or concentrated solutions. The proposed instrument will help the PI and the Co-PIs to build a comprehensive research and teaching program at the interface of physical and biological sciences at the Department of Natural Sciences, University of Michigan-Dearborn (UM-D). The present instrument will fulfill the necessary support required for various active research projects including (1) Organic Monolayers as Templates for In Situ Generation of 2D Nanoparticles, (2) Carbon Nanotube Array for DNA Detection, (3) Toxic Potential of Metallic and Magnetic Nanoparticles on Yeast Cells, (4) Gold Nanoshells as High Efficiency Selective Solar Absorbers, (5) Sperm Competition: Sperm Morphology, Storage, and Activation in Spiders, (5) Toxicological and Biomedical Characterization of Engineered Magnetic Nanoparticles and (6) Iron oxide Incorporated AOT-Alginate Nanoparticles for Drug Delivery. This instrument will expand the existing research opportunities for undergraduates to participate in the exciting multidisciplinary areas of Physical and Biological sciences. Additionally, the proposed instrument will create unique opportunities for students from diverse backgrounds, particularly; promote the participation of under-represented minorities in bio-engineering and physics. High school students from the Detroit metropolitan area will continue to obtain opportunities to participate in summer research. Layman Summary: Nanotechnology is the use of novel and unusual properties, phenomena, and processes that occur when size is reduced to 1-100 nanometers (one nanometer is one billionth of a meter). A Zeta potential and submicron particle size measurement system is an integral part of this interdisciplinary area of science due to its unique measurement capability of particle size and zeta potential (related to surface charge) of the nanometer scale molecular structures present in the chemical and biological systems. The present instrument at the Department of Natural Sciences, UM-D will attract prospective students intending to work in the interdisciplinary research areas involving physical and biological sciences like nanotechnology/nanobiotechnology. In addition, this instrument will have a major impact on our existing courses involving nanotechnology and will further expand the opportunity of undergraduate student participation in number of active faculty research programs. This instrument will also be of great support to the current outreach program of the department with local community colleges and to improve the K-12 science education of the Detroit metropolitan area.

技术概述：Zeta电位和亚微米颗粒尺寸测量是新兴的纳米技术和纳米生物技术跨学科领域的一个组成部分，因为它具有测量化学和生物系统中纳米材料尺寸和表面电荷的独特能力。目前的仪器将提供全方位的测量能力，理想的研究领域，从材料科学到进化生物学。它还能够测量溶液中固体表面的Zeta电位，这将有利于纳米颗粒或石墨烯表面组装的相关研究项目。此外，溶液中粒子可能的尺寸测量范围将有利于其在涉及纳米粒子、纳米壳甚至蜘蛛精子悬浮液的稀浓溶液研究中的应用。该仪器将帮助PI和co -PI在密歇根大学迪尔伯恩分校（UM-D）自然科学系建立一个综合的物理和生物科学界面的研究和教学计划。目前的仪器将满足各种活跃研究项目所需的必要支持，包括：(1)有机单层膜作为原位生成二维纳米颗粒的模板，(2)碳纳米管阵列用于DNA检测，(3)金属和磁性纳米颗粒对酵母细胞的毒性潜力，(4)金纳米壳作为高效选择性太阳能吸收剂，(5)精子竞争。精子在蜘蛛体内的形态、储存和激活；(5)工程磁性纳米颗粒的毒理学和生物医学特性；(6)氧化铁掺入aot -海藻酸盐纳米颗粒的药物递送。该仪器将扩大本科生参与物理和生物科学等令人兴奋的多学科领域的现有研究机会。此外，拟议的乐器将为来自不同背景的学生创造独特的机会，特别是；促进代表性不足的少数民族参与生物工程和物理学。来自底特律大都会区的高中生将继续获得参加暑期研究的机会。外行总结：纳米技术是利用当尺寸减小到1-100纳米（一纳米是一米的十亿分之一）时出现的新颖和不寻常的特性、现象和过程。Zeta电位和亚微米粒度测量系统是这一跨学科科学领域的一个组成部分，因为它具有独特的测量化学和生物系统中纳米级分子结构的粒度和Zeta电位（与表面电荷有关）的能力。澳大自然科学系的现有仪器将吸引有意从事涉及物理和生物科学（如纳米技术/纳米生物技术）的跨学科研究领域工作的未来学生。此外，该仪器将对我们现有的涉及纳米技术的课程产生重大影响，并将进一步扩大本科生参与一些活跃的教师研究项目的机会。该工具还将极大地支持该部门目前与当地社区学院的外展计划，并改善底特律大都会地区的K-12科学教育。