Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide

策划生殖：Kisspeptin 和 RFamide 相关肽

• 批准号: FT0990986
• 负责人: Dr Jeremy Smith
• 金额: $ 48.96万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2014-04-08
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT0990986
• 关键词: Masterminding; Reproduction; Kisspeptin; RFamide; Related

There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precocious puberty. Kisspeptin and RF-related peptide may offer more physiological alternatives to GnRH, without detrimental side effects. We will fully explore these two newly defined and major players in reproduction and provide a physiological framework for their progression to clinical use.

在生殖健康方面有一些令人担忧的趋势。女性报告难以怀孕和维持怀孕;而男性的精子数量和质量正在下降。更令人担忧的是生殖系统癌症的增加。促性腺激素释放激素（GnRH）拮抗剂和激动剂已被用于治疗生殖系统癌症（如乳腺癌和前列腺癌）、不孕症和性早熟数十年。Kisspeptin和RF相关肽可能为GnRH提供更多的生理替代品，而不会产生有害的副作用。我们将充分探讨这两个新定义的和主要的球员在生殖，并提供一个生理框架，其进展到临床使用。