Masterminding Reproduction: Kisspeptin and RFamide-Related Peptide

在生殖健康方面有一些令人关切的趋势。妇女报告难以怀孕和维持妊娠；男性的精子数量和质量都在下降。更令人担忧的是生殖癌症的增加。促性腺激素释放激素（GnRH）拮抗剂和激动剂几十年来一直用于治疗生殖癌症（如乳腺癌和前列腺癌）、不孕症和性早熟。Kisspeptin和rf相关肽可能为GnRH提供更多的生理替代品，而没有有害的副作用。我们将充分探讨这两种新定义的主要生殖参与者，并为它们的临床应用提供生理框架。

There are a number of concerning trends in reproductive health. Women are reporting difficulty conceiving and maintaining pregnancies; while sperm count and quality are declining in men. More concerning is the increase in reproductive cancers. Gonadotropin-releasing hormone (GnRH) antagonist and agonist have been used for decades to treat reproductive cancers (such as breast cancer and prostate cancer), infertility and precocious puberty. Kisspeptin and RF-related peptide may offer more physiological alternatives to GnRH, without detrimental side effects. We will fully explore these two newly defined and major players in reproduction and provide a physiological framework for their progression to clinical use.