Interferon-upregulated eIF2alpha Kinases in Fish

鱼类中干扰素上调的 eIF2α 激酶

• 批准号: 1049014
• 负责人: Rosemary Jagus
• 金额: $ 10.3万
• 依托单位: University of Maryland Center for Environmental Sciences
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-25 至 2011-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1049014&HistoricalAwards=false
• 关键词: Interferon; upregulated; eIF2alpha; Kinases; Fish

Two kinases that protect cells from viral infection have been identified in zebrafish. The structure of one has features that distinguish it from its mammalian counterpart. The other is unique to fish. The activities of these two enzymes will be characterized and compared in the laboratory and their expression will be investigated in cultured zebrafish cells and zebrafish in response to infection and immune stimulators. On a broader level, the results derived from this project will provide tools for the investigation of fish responses to infection. The work will benefit society by contributing to the aquaculture industry since a better knowledge of the fish immune system is essential to the development of the aquatic animal health sector. A wider understanding of these kinases also has the potential to provide tools to assess health and nutritional status of wild and captive fish populations. The project will also provide research experiences/training to high school students, undergraduate interns and area high school teachers. It will also support the training of a minority Ph.D. student.

在斑马鱼中已经鉴定出两种保护细胞免受病毒感染的激酶。 其中一个的结构特征使其区别于哺乳动物。 另一种是鱼类特有的。 这两种酶的活性将在实验室中进行表征和比较，并将在培养的斑马鱼细胞和斑马鱼对感染和免疫刺激剂的反应中研究它们的表达。 在更广泛的层面上，该项目的结果将为调查鱼类对感染的反应提供工具。 这项工作将通过对水产养殖业的贡献而造福社会，因为更好地了解鱼类免疫系统对水生动物健康部门的发展至关重要。 更广泛地了解这些激酶也有可能提供工具，以评估野生和圈养鱼类种群的健康和营养状况。 该项目还将为高中生、本科实习生和地区高中教师提供研究经验/培训。 它还将支持培养一名少数民族博士。学生.