FOR 1756: Functional Dynamics of Cell Contacts in Cellular Assemblies and Migratory Cells

FOR 1756：细胞组件和迁移细胞中细胞接触的功能动力学

• 批准号: 200509276
• 金额: --
• 依托单位: Arbeitsgruppe Entwicklungsgenetik
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/200509276?language=en
• 关键词: 1756; Functional; Dynamics; Cell; Contacts

A central element in tissue morphogenesis is the dynamics of cell-cell contacts, i.e. their formation, dissolution, rearrangement and maintenance. The molecules underlying specific cell-cell contacts are adhesion molecules and cell surface ligand-receptor systems. The dynamic cell contacts determine specific cellular behaviour and constitute the driving force for tissue elongation, cell rearrangement, cell sorting, cell migration and cell-cell association. The Research Unit focusses on defining and analysing the functional dynamics of cell contacts in cellular assemblies and small sets of cells in a set of genetically tractable model systems. Specifically, the Research Unit aims at identifying and investigating the biomechanical mechanisms underlying the dynamics of cell contacts, define the molecular mechanisms responsible for the biomechanical properties and identify and characterise novel components involved in cell contacts.

组织形态发生中的中心要素是细胞-细胞接触的动力学，即它们的形成、溶解、重排和维持。细胞间特异性接触的基础分子是粘附分子和细胞表面配体-受体系统。动态细胞接触决定特定的细胞行为，并构成组织伸长、细胞重排、细胞分选、细胞迁移和细胞-细胞缔合的驱动力。该研究单位专注于定义和分析细胞组件和一组遗传上易于处理的模型系统中的小组细胞中细胞接触的功能动力学。具体来说，研究单位的目的是确定和调查细胞接触动力学的生物力学机制，确定负责生物力学特性的分子机制，并确定和识别涉及细胞接触的新组件。