Septins in fungal development

真菌发育中的脓毒症

• 批准号: 1051730
• 负责人: Michelle Momany
• 金额: $ 46万
• 依托单位: University of Georgia Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1051730&HistoricalAwards=false
• 关键词: Septins; fungal; development

Septins are an important part of the cytoskeleton, an intricate and tightly-regulated network that organizes and supports structures and directs traffic of building materials inside cells. Even though they were discovered relatively recently, it is already clear that septins are critical for orderly cell division and for development, the process by which cells take on specialized roles within multicellular organisms. Much has been learned about how septins work through studies in the simple single-celled fungus Saccharomyces cerevisiae (budding yeast). Questions about how septins coordinate development in more complex, multi-cellular organisms cannot be addressed in yeast. In this project, the role of septins in the multicellular fungus Aspergillus nidulans will be investigated using genetic, cellular biology and biochemical approaches. The focus will be on finding out how septins work with each other and with other parts of the cytoskeleton during early stages of multicellular development. This project is expected to identify new ways in which the individual cells within multicellular organisms communicate with each other and coordinate growth and development across different cell types. Since much of the cell division machinery is the same in animals and fungi, the project will have a broad scientific impact. The project will provide outstanding training opportunities at the undergraduate, graduate and postdoctoral levels. Trainees will be mentored in the conduct of research, have opportunities to present their work in a variety of settings and develop their skills as communicators and teachers.

脓毒症是细胞骨架的重要组成部分，细胞骨架是一个复杂且严格调控的网络，用于组织和支持结构并指导细胞内建筑材料的运输。尽管它们是最近才发现的，但人们已经清楚，脓毒症对于有序的细胞分裂和发育（细胞在多细胞生物体中发挥特殊作用的过程）至关重要。 通过对简单单细胞真菌酿酒酵母（芽殖酵母）的研究，我们已经了解了很多关于脓毒症如何发挥作用的知识。 关于脓蛋白如何协调更复杂的多细胞生物体发育的问题无法在酵母中得到解决。在该项目中，将利用遗传、细胞生物学和生化方法研究脓毒蛋白在多细胞真菌构巢曲霉中的作用。 重点将在于找出在多细胞发育的早期阶段，脓毒症如何彼此以及与细胞骨架的其他部分相互作用。 该项目预计将确定多细胞生物体内各个细胞相互沟通并协调不同细胞类型生长和发育的新方式。 由于动物和真菌的大部分细胞分裂机制是相同的，因此该项目将产生广泛的科学影响。 该项目将为本科生、研究生和博士后水平提供出色的培训机会。 学员将接受研究指导，有机会在各种环境中展示他们的工作，并培养他们作为沟通者和教师的技能。