EAGER: Ultraminiature Imaging Systems for Biomedical Applications

1053204 Tanguay这个潜在的变革性研究项目的基本目标是研究超小型摄像机的超紧凑光学成像系统的可行性，该系统设计用于人体慢性手术植入以及微创内窥镜检查。这种超小型摄像机的生物医学成像应用包括长期植入式摄像机，超小型内窥镜，用于视网膜假体的眼内摄像机，用于视网膜假体的宽视场眼跟踪眼外摄像机以及小型化眼跟踪摄像机。和测试超小型光学系统，既紧凑又低质量，以允许手术植入;在这种高度小型化的光学系统中通过超小形状因子折射和混合折射/衍射光学元件;研究设计原理，用于开发针对生物医学成像应用进行优化的低功耗、低形状因子CMOS图像传感器阵列，并通过视觉心理物理学技术评估生物医学应用中像素化图像的图像前和图像后滤波的重要性，以便为这些新颖的光学成像系统建立适当的设计约束。

1053204TanguayThe fundamental goal of this potentially transformative research project is to investigate the feasibility of ultracompact optical imaging systems for ultraminiature cameras designed for chronic surgical implantation in the human body, as well as for minimally invasive endoscopic examinations. Biomedical imaging applications of such ultraminiature cameras include chronically implantable cameras, ultraminiature endoscopes, an intraocular camera for retinal prostheses, a wide field-of-view eye-tracked extraocular camera for retinal prostheses, and a miniaturized eyetracking camera.The principal research activities enabled by this grant will include theoretical analysis, fabrication, and test of ultraminiature optical systems that are both compact and low-mass to allow for surgical implantation; the incorporation of optimized imaging capability in such highly miniaturized optical systems by means of ultra-small form factor refractive and hybrid refractive/diffractive optical elements; the investigation of design principles for the development of low power, low form factor CMOS image sensor arrays that are optimized for biomedical imaging applications, and the assessment by means of visual psychophysics techniques of the importance of pre- and post-image filtering of pixellated images for biomedical applications, in order to establish appropriate design constraints for these novel optical imaging systems.