EAGER: Ultraminiature Imaging Systems for Biomedical Applications

[5334 . 04]这个潜在的变革性研究项目的基本目标是研究用于人体慢性手术植入的微型相机的超紧凑光学成像系统的可行性，以及用于微创内窥镜检查的可行性。这种超微型相机的生物医学成像应用包括慢性植入式相机、超微型内窥镜、用于视网膜假体的眼内相机、用于视网膜假体的大视场眼外跟踪相机和小型化眼追踪相机。该基金的主要研究活动将包括理论分析、制造和超微型光学系统的测试，该系统既紧凑又低质量，可以进行手术植入；通过超小型折射光学元件和混合折射/衍射光学元件，在这种高度小型化的光学系统中集成优化的成像能力；研究针对生物医学成像应用优化的低功耗、低外形因数CMOS图像传感器阵列的设计原则，并通过视觉心理物理学技术评估像素化图像预处理和后期滤波对生物医学应用的重要性，以便为这些新型光学成像系统建立适当的设计约束。

1053204TanguayThe fundamental goal of this potentially transformative research project is to investigate the feasibility of ultracompact optical imaging systems for ultraminiature cameras designed for chronic surgical implantation in the human body, as well as for minimally invasive endoscopic examinations. Biomedical imaging applications of such ultraminiature cameras include chronically implantable cameras, ultraminiature endoscopes, an intraocular camera for retinal prostheses, a wide field-of-view eye-tracked extraocular camera for retinal prostheses, and a miniaturized eyetracking camera.The principal research activities enabled by this grant will include theoretical analysis, fabrication, and test of ultraminiature optical systems that are both compact and low-mass to allow for surgical implantation; the incorporation of optimized imaging capability in such highly miniaturized optical systems by means of ultra-small form factor refractive and hybrid refractive/diffractive optical elements; the investigation of design principles for the development of low power, low form factor CMOS image sensor arrays that are optimized for biomedical imaging applications, and the assessment by means of visual psychophysics techniques of the importance of pre- and post-image filtering of pixellated images for biomedical applications, in order to establish appropriate design constraints for these novel optical imaging systems.