CAREER:Asymmetric Silylation of Secondary Alcohols and Mechanistic Investigations

南卡罗来纳大学的Sheryl L.Wiskur教授得到了化学系化学催化(CAT)计划的支持，以开发一项专注于醇的不对称硅基化的研究项目。硅基的不对称衍生化将通过选择性动力学拆分来实现一种醇对映体对另一种醇对映体的浓缩。这将导致单一对映体的对映体过量增加，并最终以更高的产率高度浓缩化合物。利用核磁共振和圆二色谱对硅烷化动力学拆分的机理和手性诱导的起源进行了详细的研究。手性醇是合成多种手性产品的常用原料，具有重要的理论意义和实用价值。一种简便的合成方法可以获得更高的单一对映体的产率，这将对制药和农化工业产生重大影响。学生将接受有机化学和分析化学技能的培训，为他们在学术、制药和工业化学职业中做好准备。女性和少数民族学生将接受培训，以提高他们的科学、领导和管理技能。

Professor Sheryl L. Wiskur of the University South Carolina is supported by the Chemical Catalysis (CAT) Program in the Division of Chemistry to develop a research project with a focus on the asymmetric silylation of alcohols. Asymmetric derivatization with silyl groups will be employed to bring about the enrichment of one alcohol enantiomer over another via selective kinetic resolutions. These will lead to an increase in the enantiomeric excess of single enantiomers and ultimately highly enriched compounds in higher yields. Detailed studies are also proposed using NMR and circular dichroism to elucidate the mechanistic pathway of silylation-based kinetic resolutions and the origin of chiral induction. The proposed research is of fundamental and practical importance.Chiral alcohols are common starting materials for a variety of chiral products. A facile synthetic procedure to obtain higher yields of single enantiomers will have a significant impact on the pharmaceutical and agrochemical industries. Students will be trained in organic and analytical chemistry skills to prepare them for academic, pharmaceutical and industrial chemical careers. Women and minority students will be coached to sharpen their scientific, leadership and management skills.