CAREER:Asymmetric Silylation of Secondary Alcohols and Mechanistic Investigations

Sheryl L.教授南卡罗来纳州大学的Wiskur得到化学系化学催化（CAT）项目的支持，开发了一个研究项目，重点是醇的不对称硅烷化。与甲硅烷基基团的不对称衍生化将被用来通过选择性动力学拆分使一种醇对映体相对于另一种醇对映体富集。这些将导致单一对映异构体的对映异构体过量的增加，并最终以更高的产率高度富集化合物。详细的研究也提出了使用NMR和圆二色性来阐明基于硅烷化的动力学拆分的机理途径和手性诱导的起源。手性醇是合成各种手性产物的常用原料，因此，本文的研究具有重要的理论和实际意义。一个简单的合成方法，以获得更高的单一对映体的收率将有显着的影响，医药和农药工业。学生将接受有机和分析化学技能的培训，为他们的学术，制药和工业化学职业做好准备。妇女和少数民族学生将接受辅导，以提高他们的科学，领导和管理技能。

Professor Sheryl L. Wiskur of the University South Carolina is supported by the Chemical Catalysis (CAT) Program in the Division of Chemistry to develop a research project with a focus on the asymmetric silylation of alcohols. Asymmetric derivatization with silyl groups will be employed to bring about the enrichment of one alcohol enantiomer over another via selective kinetic resolutions. These will lead to an increase in the enantiomeric excess of single enantiomers and ultimately highly enriched compounds in higher yields. Detailed studies are also proposed using NMR and circular dichroism to elucidate the mechanistic pathway of silylation-based kinetic resolutions and the origin of chiral induction. The proposed research is of fundamental and practical importance.Chiral alcohols are common starting materials for a variety of chiral products. A facile synthetic procedure to obtain higher yields of single enantiomers will have a significant impact on the pharmaceutical and agrochemical industries. Students will be trained in organic and analytical chemistry skills to prepare them for academic, pharmaceutical and industrial chemical careers. Women and minority students will be coached to sharpen their scientific, leadership and management skills.