Reactivity of 1,2-Biradicals and Their Use in Applications

1,2-双自由基的反应性及其应用

• 批准号: 1057481
• 负责人: Anna Gudmundsdottir
• 金额: $ 43.34万
• 依托单位: University of Cincinnati Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-10-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1057481&HistoricalAwards=false
• 关键词: Reactivity; Biradicals; Their; Use; Applications

The Chemical Structure, Dynamics and Mechanisms Program supports Professor Anna Gudmundsdottir of the University of Cincinnati who will develop a fundamental understanding of the reactivity of simple triplet 1,2 diradicals and how they can be used to initiate photorelease from hydroxyphenyl-crotoane ester derivatives. Not knowing the mechanism and the rate of the release from these hydroxyphenylcrotoane ester derivatives prevents their use as photoremovable photoprotecting groups (PRPGs). The long-term goal is to design PRPGs to study molecular motors. The objective of this work is to determine the mechanism for triplet photoisomerization of simple alkenes and vinyl azides and explore if triplet 1,2-biradical can be formed selectivity and if they can be used to both release alcohols from PRPGs and to form triplet vinyl nitrenes. The proposed research will result in a better understanding of the reactivity of triplet 1,2-biradicals and vinyl nitrenes. Furthermore, the proposed research will lead to new PRPGs and the elucidation of the mechanism for release from these PRPGs.With the support of the Chemical Structure, Dynamics and Mechanisms Program in the Chemistry Division at the National Science Foundation, Professor Anna Gudmundsdottir performs research that will potentially impact physiology studies since these PRPGs can be used to study physiological events in living systems. Furthermore, understanding the mechanism for photorelease from the proposed PRPGs will make it possible to design a new generation of PRPGs that can be used in various applications, such as delivering drugs, and releasing fragrances and bug repellent in household products. The PI proposes to implement a program by attracting both high school and undergraduate students, with a focus on attracting underrepresented students to do research in various research groups within the Chemistry Department, including the PI's, and also to provide these students with educational activities that focus on their professional development. Thus, the proposed research and the developmental teaching will lead to enhanced infrastructure within the PI's department and serve as an outreach program, for example, at the Central State University Chemistry Department and other schools in the region. Advancement of these students is expected to have a broad societal impact, complemented by the positive effect that the research outcomes are expected to have.

化学结构、动力学和机理计划支持辛辛那提大学的Anna Gudmundsdottir教授，她将对简单的三重1，2双自由基的反应性以及如何使用它们引发羟基苯基巴豆烷酯衍生物的光释放有基本的了解。由于不知道这些羟基苯基巴豆烷酯类化合物的释放机理和释放速率，阻碍了它们作为光可移除光保护基团(PRPG)的使用。长期目标是设计PRPG来研究分子马达。这项工作的目的是确定单烯和乙烯基叠氮化物的三重线光异构化机理，并探索是否可以选择性地形成三重1，2-双自由基，以及它们是否可以用于从PRPG中释放醇和形成三重乙烯基硝烯。这项拟议的研究将有助于更好地理解三重态1，2-双自由基和乙烯基硝烯的反应性。此外，拟议的研究将导致新的PRPG和从这些PRPG释放的机制的阐明。在国家科学基金会化学部化学结构、动力学和机制计划的支持下，Anna Gudmundsdottir教授进行了可能会影响生理学研究的研究，因为这些PRPG可以用于研究生命系统中的生理事件。此外，了解拟议PRPG的光释放机制将使设计新一代PRPG成为可能，这些PRPG可用于各种应用，如输送药物，以及在家用产品中释放香料和驱虫剂。国际学生联合会建议通过吸引高中生和本科生来实施一项计划，重点是吸引代表性不足的学生在化学系内的各种研究小组(包括国际学生联合会)进行研究，并为这些学生提供以专业发展为重点的教育活动。因此，拟议的研究和发展性教学将加强国际和平研究所内部的基础设施，并作为一个外联方案，例如在中央州立大学化学系和该地区的其他学校。这些学生的进步预计将产生广泛的社会影响，并辅之以预期研究成果将产生的积极影响。