CAREER: Photolysis of Alkylazides in Solution and in Crystals

有机和大分子化学计划通过该职业奖支持俄亥俄州辛辛那提市辛辛那提大学化学系Anna D. Gudmundsdottir博士的工作。本研究涉及烷基亚硝基中间体在溶液和固体中的形成、检测和反应性的研究，重点是烷基叠氮化物光解过程中形成的三重态亚硝基。使用可见光/紫外和红外光谱的组合和产品分析来研究的叠氮化物包括叠氮苯乙酮、-、-和-叠氮芳基酮、苄基叠氮化物和氟化2-叠氮乙基苯。Gudmundsdottir提议研究一类含有饱和碳原子与不饱和氮原子结合的高活性有机分子的光谱特性和反应性。这些亚硝基烯将在溶液或晶体固体中使用激光闪光光解产生，并且可能包含两个具有平行或反平行自旋的电子（三重态或单线态电子），通常导致不同的产品。更好地了解固态下的这些反应有望导致更好地设计用于新材料的有机晶体。可能的应用包括光刻、生物分子的光亲和性标签和有机磁体。学生们将通过开展研究和参加研讨会课程来学习，在研讨会课程中，他们将接触到许多成功的科学家，包括来自工业界和代表性不足的少数民族的代表。这些研讨会将帮助学生们决定离开辛辛那提大学后要走什么样的职业道路。

With this CAREER award the Organic and Macromolecular Chemistry Program supports the work of Dr. Anna D. Gudmundsdottir in the Department of Chemistry at the University of Cincinnati in Cincinnati, Ohio. The research involves forming, detecting, and investigating the reactivity of alkyl nitrene intermediates in solution and in the solid state, emphasizing triplet nitrenes formed in the photolysis of alkyl azides. The azides to be studied, using a combination of vis/uv and IR spectroscopies and product analysis, include azidoacetophenone, beta-, gamma-, and delta-azidoarylketones, benzyl azide, and fluorinated 2-azidoethyl benzene.Dr. Gudmundsdottir proposes to study the spectroscopic properties and reactivity of a class of highly reactive organic molecules which contain a saturated carbon atom bound to an unsaturated nitrogen atom. These nitrenes will be generated in solution or in crystalline solids using laser flash photolysis, and may contain two electrons with parallel or antiparallel spins (triplet or singlet electronic states), often leading to different products. Better understanding of these reactions in the solid state is expected to lead to better design of organic crystals for new materials. Possible applications include photolithography, photoaffinity labels for biological molecules, and organic magnets. Students will learn both from carrying out the research and by participating in a seminar course where they will be exposed to a number of successful scientists, including representatives from industry and from underrepresented minorities. The seminars will help the students decide what career paths to follow once they leave the University of Cincinnati.