Mechanisms of cell-cell contact induced activity modulation in myeloid leukocytes (B02)

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The activity of immune cells is regulated by external factors derived from pathogens or tissue injury, but also by direct cell-cell contacts. Here, we will investigate how direct interactions between neutrophils and macrophages influence their mutual functional state by performing in vivo calcium imaging. Next, we will determine the role of chemokines, integrins, and calcium channels in this interplay. Finally, we will manipulate calcium levels during cell-cell contacts to analyse the importance of calcium oscillations for this process. This will give new insights into inflammatory processes and how they can be targeted.