Mitochondrial cell biology: Understanding the molecular mechanisms and functions of mitochondrial dynamics and membrane contact sites

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Mitochondria form a dynamic and connected network, which is constantly remodelled by cycles of membrane fission and fusion. These dynamic transitions are not only required to ensure a proper mitochondrial function but also to respond to cellular needs and adapt to the metabolic state of the cell. To execute cellular functions, mitochondria also establish membrane contact sites with other organelles, including the endoplasmic reticulum, peroxisomes and lysosomes. These organelle membrane contact sites are hotspots for metabolites flux and tightly regulate mitochondrial architecture. While defects in mitochondrial morphology or contact sites have been associated with human diseases, the molecular mechanisms linking mitochondrial membrane remodelling to cell fate decisions are poorly understood. The Prudent group focusses on understanding the mechanisms regulating membrane dynamics and remodelling, how they influence cellular functions and govern cell fate decisions. In our first research aim, we employ state-of-the-art to identify and functionally characterise new proteins regulating mitochondrial morphology and mitochondria-organelle contact sites, and how they govern cell fate decisions. Our second aim of research is to elucidate how mitochondrial membrane remodelling regulates mitochondrial (mt)DNA quality control and modulates cytosolic mtDNA release driving inflammation to control cellular homeostasis.