Turnover and recycling of the peptidoglycan-teichoic acid complex of Gram-positive cell wall (A15)

革兰氏阳性细胞壁肽聚糖-磷壁酸复合物的周转和再循环（A15）

• 批准号: 200819612
• 金额: --
• 依托单位: Lehrstuhl Organismische Interaktionen
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/200819612?language=en
• 关键词: Turnover; recycling; peptidoglycan; teichoic; acid

Our goal is to establish the turnover and recycling metabolism of the peptidoglycan-wall teichoic acid (PG-WTA) complex in Bacillus subtilis. We aim to answers the following questions: (i) which fragments are released from the cell wall at the different stages of the cell cycle (elongation, cell division/separation) as well as during spore formation, (ii) which transport proteins and pathways are used to import and reutilize (recycle) these compounds, and (iii) how is cell wall autolysis and recycling regulated, and are particular PG-WTA turnover products used to monitor the state of the cell wall or to time the cell cycle?

我们的目标是在枯草芽孢杆菌中建立肽聚糖-壁磷壁酸(PG-WTA)复合体的周转和循环代谢。我们的目标是回答以下问题：(I)在细胞周期的不同阶段(伸长、细胞分裂/分离)以及孢子形成期间，哪些片段从细胞壁释放出来；(Ii)哪些运输蛋白和途径被用于输入和再利用(再循环)这些化合物；(Iii)如何调节细胞壁的自溶和再循环，以及特定的PG-WTA周转产物是否用于监测细胞壁的状态或对细胞周期进行计时？