US Egypt Cooperative Research: Nanomaterials for Improving Biomedical Imaging and Early Diagnosis of Cancer

美埃合作研究：改善生物医学成像和癌症早期诊断的纳米材料

• 批准号: 1103935
• 负责人: Stanislav Emelianov
• 金额: $ 11.5万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1103935&HistoricalAwards=false
• 关键词: US; Egypt; Cooperative; Research; Nanomaterials

1103935 This project supports a cooperative research project by Dr. Stanislav Emelianov, University of Texas at Austin and Dr. Hassan Talaat, Ain Shams University, Cairo. They plan to study nanomaterials for developing devices for Improving Biomedical Imaging and Early Diagnosis of Cancer. Photothermal therapy, a targeted, non-invasive treatment of cancer where heat is used to cause tumor necrosis, is a suitable alternative to traditional surgery when surgery is impossible. The PIs plan a combined ultrasound and photoacoustic imaging system to non-invasively assist, guide and monitor photothermal cancer therapy. Metal nanoparticles will be developed as optically tuned photoabsorbers to efficiently transfer light irradiation into thermal energy to the tumor. Further, bioconjugation protocols will be designed to specifically target the photoabsorbers to cancerous cells. Ultrasound imaging will be utilized to identify the anatomy of the tumor while photoacoustic imaging will be used to ensure the presence of photoabsorbers before beginning therapy. Both ultrasound and photoacoustic imaging will be used to monitor temperature during therapy to ensure tumor necrosis and protect the surrounding healthy tissue. Finally, ultrasound imaging can track thermal damage in real-time during and after therapy to ensure cancer destruction. Ultrasound-guided molecular photoacoustic imaging and photothermal therapy will have a major impact in breast oncology. Intellectual merits: The main objective of this proposal is to design a prototype device for biomedical imaging based on using the photoacoustic tomography technique and different nanomaterials as contrast agents. The activity does carry a potential to advance our knowledge and understanding within the photoacoustic and ultrasound imaging field as well as nanotechnology and medicine. Nanomaterials and photoacoustic biomedical imaging are both emerging technologies in its own field. Integrating these two technologies in this proposed study will form an important foundation and guidelines to design and develop a hybrid imaging/therapy system for biomedical applications such as cancer treatments. The multi-disciplinary team consists of experts in nanotechnology and photoacoustic biomedical imaging. The roles of each coordinator are well defined and the collaborating mechanisms are adequately planned. This project involves exploring original and potentially transformative concepts of combining novel imaging strategies and advancing potentially new cancer therapies. Broader impacts: Highly beneficial education and training of students, postdoctoral fellows, and junior faculties in the wide spectrum of the research areas of nanotechnology, biomedical imaging and medicine are expected. The already established network between UT and ASU will be strengthened and the successful outcomes of this project may lead a strong industrial partnership between US and Egypt with high potential. If successful, this hybrid technology may eventually bring an important imaging/therapy tool for the cancer treatments in clinic. The activity aims to broaden the participation of under-represented groups specifically women. Successful outcomes could greatly improve the multi-modal imaging techniques and would significantly advance the field. Indeed, the developed technology will be able to identify molecular composition of cancer and functional changes during image-guided photothermal therapy. The research will impact the fields of cancer research and clinical oncology as the developed methods and approaches can be applied in wide range of applications.This proposal is supported under the US-Egypt Joint Fund Program where NSF supports the US side and the Government of Egypt funds the Egyptian side.

1103935本项目支持奥斯汀德克萨斯大学Stanislav Emelianov博士和开罗艾因沙姆斯大学Hassan Talaat博士的合作研究项目。他们计划研究纳米材料，用于开发改善生物医学成像和癌症早期诊断的设备。光热疗法是一种有针对性的、非侵入性的癌症治疗方法，利用热量引起肿瘤坏死，在无法进行手术的情况下，它是传统手术的一种合适的替代方法。pi计划将超声和光声成像系统结合起来，以非侵入性地辅助、指导和监测光热癌症治疗。金属纳米颗粒将作为光调谐光吸收剂，有效地将光照射转化为热能到肿瘤。此外，生物偶联方案将被设计为专门针对癌细胞的光吸收剂。超声成像将用于确定肿瘤的解剖结构，而光声成像将用于确保在开始治疗前存在光吸收剂。超声和光声成像将用于监测治疗过程中的温度，以确保肿瘤坏死和保护周围的健康组织。最后，超声成像可以在治疗过程中和治疗后实时跟踪热损伤，以确保癌症的破坏。超声引导分子光声成像和光热治疗将对乳腺肿瘤学产生重大影响。智力优势：本提案的主要目标是设计一个基于光声断层成像技术和不同纳米材料作为造影剂的生物医学成像原型设备。这项活动确实有可能促进我们在光声和超声成像领域以及纳米技术和医学领域的知识和理解。纳米材料和光声生物医学成像都是各自领域的新兴技术。将这两种技术整合到本研究中，将为设计和开发用于生物医学应用（如癌症治疗）的混合成像/治疗系统奠定重要的基础和指导方针。多学科团队由纳米技术和光声生物医学成像专家组成。每个协调器的角色都有很好的定义，协作机制也有充分的规划。该项目包括探索结合新颖成像策略和推进潜在的新癌症治疗的原始和潜在的变革概念。更广泛的影响：期望在纳米技术、生物医学成像和医学等广泛的研究领域为学生、博士后研究员和初级教员提供非常有益的教育和培训。UT和ASU之间已经建立的网络将得到加强，这个项目的成功成果可能会导致美国和埃及之间具有巨大潜力的强大工业伙伴关系。如果成功，这种混合技术可能最终为临床癌症治疗带来重要的成像/治疗工具。这项活动的目的是扩大代表性不足的群体，特别是妇女的参与。成功的结果可以极大地改善多模态成像技术，并将显著推动该领域的发展。事实上，这项开发的技术将能够在图像引导光热治疗过程中识别癌症的分子组成和功能变化。该研究将对癌症研究和临床肿瘤学领域产生影响，因为所开发的方法和方法具有广泛的应用前景。该提议得到了美国-埃及联合基金项目的支持，其中美国国家科学基金会支持美方，埃及政府资助埃及方面。