US Egypt Cooperative Research: Luminescent Molecularly Imprinted Polymer Sensor Arrays

美埃合作研究：发光分子印迹聚合物传感器阵列

• 批准号: 1103904
• 负责人: Ken Shimizu
• 金额: $ 12.5万
• 依托单位: University South Carolina Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1103904&HistoricalAwards=false
• 关键词: US; Egypt; Cooperative; Research; Luminescent

1103904 This project supports a cooperative research project by Dr. Ken Shimizu, University of South Carolina, Columbia, SC and Dr. Hasan Azab (Ibrahim) of the Suez Canal University, Ismailia, Egypt. They plan to study luminescent molecularly imprinted polymer (MIPs) sensor arrays by combining (1) the selective luminescent properties of lanthanide-analyte coordination complexes with (2) the shape and functional group selectivity of molecular imprint polymers (MIPs).Intellectual Merit: The increasing use of pesticides has led to greatly improved crop yieldsand agricultural productivity. However, this has also lead to the increasing problem of thecontamination of water supplies and food products with pesticide residues. The goal of thisproject is to develop luminescent polymeric sensor arrays that can identify and measure theconcentrations of common pesticides in water. The luminescent imprinted polymer sensor arrayswill have long shelf-lives, yield rapid results, and require minimal of instrumentation.The sensor arrays are comprised of different molecularly imprinted polymers that contain lanthanidebinding sites. Each polymer in the array will be synthesized in the presence of a differentpesticide or pesticide analog, which will allow the sensor arrays to be rationally tailoredwith selectivity to specific groups or classes of analytes. The arrays will be highly sensitiveand selective due to the luminescent lanthanide coordination sites that have high affinityand provide a very strong and easily measured change in emissive properties upon binding thetarget analytes. The collaboration involves DR. Hassan Azab who is an expert on the synthesis and characterization of luminescent lanthanide sensors and Dr. Ken D. Shimizu who is an expertthe synthesis and analysis of molecularly imprinted polymer sensor arrays.Broader Impacts: The technological broader impact will be the development of new rapid andinexpensive methods for monitoring water purity and food safety. In addition, the new sensingplatform can also be readily adapted to target other analytes of interest such as pharmaceuticals,environmental pollutants and disease indicators. This international collaboration will alsoprovide a venue for the exchange of scientific expertise and the training of participatinggraduate students. Monthly video-conferencing meetings will be held to allow participantsto practice their presentation and communication skills, as well as, to exchange information.The PIs will have exchange visits in each of the first two years to coordinate the project.This proposal is supported under the US-Egypt Joint Fund Program where NSF supports the US side and the Government of Egypt funds the Egyptian side.

1103904 该项目支持哥伦比亚南卡罗来纳州大学Ken Shimizu博士和埃及伊斯梅利亚苏伊士运河大学Hasan Azab博士（Ibrahim）的合作研究项目。 他们计划通过结合（1）镧系元素-分析物配位络合物的选择性发光特性和（2）分子印迹聚合物（MIPs）的形状和官能团选择性来研究发光分子印迹聚合物（MIPs）传感器阵列。智力优势：农药的日益使用大大提高了农作物产量和农业生产力。然而，这也导致了越来越多的水供应和食品被农药残留污染的问题。本项目的目标是开发发光聚合物传感器阵列，可以识别和测量水中常见农药的浓度。发光印迹聚合物传感器阵列将具有较长的保质期，产生快速的结果，并需要最少的仪器。传感器阵列由不同的分子印迹聚合物组成，这些聚合物含有镧系元素结合位点。阵列中的每种聚合物都将在不同的农药或农药类似物存在下合成，这将允许传感器阵列对特定的分析物群体或类别进行合理的选择性调整。由于发光镧系元素配位位点具有高亲和力，并在结合目标分析物时提供非常强且易于测量的发射性质变化，因此阵列将是高度灵敏和选择性的。这项合作涉及哈桑阿扎卜博士，他是一个发光镧系元素传感器的合成和表征专家，和肯D。更广泛的影响：技术上更广泛的影响将是开发新的快速和廉价的方法来监测水的纯度和食品安全。此外，新的传感平台还可以很容易地适应目标其他感兴趣的分析物，如药物，环境污染物和疾病指标。这种国际合作也将为科学专业知识的交流和参与研究生的培训提供一个场所。每月将举行视频会议，让参与者练习他们的演讲和沟通技巧，以及，交换信息。PI将在头两年每年进行互访，以协调该项目。该提案得到了美国-埃及联合基金计划的支持，NSF支持美方，埃及政府资助埃及方面。