New Strategies for Improved Molecuarly Imprinted Polymers

改进分子印迹聚合物的新策略

• 批准号: 0828897
• 负责人: Ken Shimizu
• 金额: $ 25万
• 依托单位: University South Carolina Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0828897&HistoricalAwards=false
• 关键词: New; Strategies; Improved; Molecuarly; Imprinted

CBET-0828897ShimizuThis NSF award by the Chemical and Biological Separations program supports work by Professor Ken D. Shimizu at the University of South Carolina at Columbia to develop polymers with recognition properties for use in chromatography and sensing applications. The molecular imprinting approach will be utilized to quickly and efficiently prepare polymers with desired affinities and selectivities. However, the imprinting process is also a low fidelity process that generates binding sites with a wide range of structures, affinities, and selectivities. This binding site heterogeneity has hindered the wider adoption of molecularly imprinted materials. Three new molecular imprinting strategies have been developed to specifically address the problem of binding site heterogeneity in imprinted polymers. These are: 1) development of multifunctional monomers, 2) site-specific post-modification strategies, and 3) template activated monomers. An advantage of these new strategies is that they can be used in tandem to optimize and tailor the binding properties of the polymers for specific applications. To demonstrate the utility of these new methods, imprinted polymers will be developed for use in an enantiomeric excess (ee) assay and for use as a chiral separation support in a HPLC column. The broader impacts of the proposed research will be development of methods to rapidly and inexpensively prepare polymers with tailored recognition properties. The improved binding properties of the imprinted materials will be widely applicable in analytical and biotechnical applications. These include catalysis, sensing, solid-phase extraction, drug delivery, and chromatography. The students working on this project will receive a highly multidisciplinary education, preparing them for research careers in polymer, pharmaceutical, and analytical chemistries. The award will also assist in supporting two outreach activities. The first is an outreach program for K-12 schools. The students are give chemical demonstrations in the areas schools with a focus on schools with a predominantly minority population. The second educational program is the development of a hands-on laboratory experience for high school students. The program brings high school classes to the University of South Carolina for a day. A molecular imprinted polymer laboratory has been designed, which exposes the students to cutting edge research. Additional interactive activities and tours are incorporated to introduce them to the scientific research environment.

CBET-0828897Shimizu这项由化学和生物分离计划颁发的NSF奖支持南卡罗来纳大学哥伦比亚分校的Ken D.Shimizu教授开发用于色谱和传感应用的具有识别特性的聚合物。分子印迹方法将被用来快速有效地制备具有所需亲和力和选择性的聚合物。然而，印迹过程也是一个低保真的过程，产生具有广泛的结构、亲和力和选择性的结合位点。这种结合位点的异质性阻碍了分子印迹材料的广泛采用。三种新的分子印迹策略已经被开发出来，专门解决印迹聚合物中结合位置的异质性问题。它们是：1)多功能单体的开发，2)特定部位的后修饰策略，3)模板活化的单体。这些新策略的一个优点是，它们可以串联使用，以针对特定应用优化和定制聚合物的结合性能。为了证明这些新方法的实用性，印迹聚合物将被开发用于对映体过量(Ee)分析，并用作高效液相色谱柱中的手性分离载体。拟议研究的更广泛影响将是开发快速和廉价地制备具有定制识别性能的聚合物的方法。改进后的印迹材料的结合性能将在分析和生物技术应用中得到广泛应用。这些技术包括催化、传感、固相萃取、药物输送和层析。从事这个项目的学生将接受高度多学科的教育，为他们在聚合物、制药和分析化学领域的研究生涯做好准备。该奖项还将协助支持两项外联活动。第一个是针对K-12学校的外展计划。学生们在该地区的学校进行化学示威，重点是以少数民族人口为主的学校。第二个教育项目是为高中生开发动手实验室体验。该项目为南卡罗来纳大学提供为期一天的高中课程。设计了一个分子印迹聚合物实验室，使学生能够接触到前沿研究。还加入了额外的互动活动和参观活动，将他们介绍给科研环境。