DISSERTATION RESEARCH: Oxidative stress and trade-offs in the cooperatively breeding Florida Scrub-Jay (Aphelocoma coerulescens)

论文研究：合作繁殖佛罗里达松鸦 (Aphelocoma coerulescens) 的氧化应激和权衡

• 批准号: 1110315
• 负责人: Stephan Schoech
• 金额: $ 1.49万
• 依托单位: University of Memphis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1110315&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Oxidative; stress; trade

Oxidative damage results from the inability of an organism to cope with reactive oxygen species (ROS) that are formed as byproducts of metabolism. Damage to various classes of biomolecules has been implicated in cellular senescence, aging and debilitating diseases. This research will be the first to address the effects of multiple aspects of oxidative damage on fitness-related measures in a free-living long-lived avian model. The framework currently being developed from this research may be of importance to the medical community as birds are increasingly being recognized as viable models to assess adaptations to combat oxidative damage, senescence, and associated diseases in humans. Florida Scrub-Jays will be used to assess whether the accumulation of oxidative damage negatively affects reproductive decisions and output, as well as fitness. Both nestling and adult birds will be supplemented with antioxidants which neutralize ROS. Thus, birds that receive antioxidants are predicted to demonstrate higher reproduction and survivorship. Florida Scrub-Jays are a federally threatened species and therefore, the results of this research may be applied broadly to assist in the conservation of this, and other threatened species by providing important clues as to the best management practices with regard to supplemental antioxidant diets. Additionally, through collaboration with Archbold Biological Station (ABS), an ecological research facility intimately involved in environmental education, this research will integrate scientific advancement with educational opportunities. This research will be published in high profile journals and presented at scientific and lay meetings. It will also be shared informally through interactions with visitors to ABS, and formally both through the station?s internship program which brings several dozen undergraduate and graduate students to the station to work on independent projects each year and the ABS ecology education program which hosts nearly 3,000 3rd-5th grade schoolchildren every year.

氧化损伤是由于生物体无法应对代谢副产物形成的活性氧 (ROS) 造成的。各类生物分子的损伤与细胞衰老、衰老和衰弱疾病有关。这项研究将首次探讨氧化损伤的多个方面对自由生活的长寿鸟类模型中健康相关指标的影响。目前从这项研究中开发的框架可能对医学界很重要，因为鸟类越来越被认为是评估人类对抗氧化损伤、衰老和相关疾病的适应性的可行模型。佛罗里达灌丛鸦将用于评估氧化损伤的积累是否会对繁殖决策和产量以及健康产生负面影响。 雏鸟和成年鸟都将补充中和活性氧的抗氧化剂。因此，接受抗氧化剂的鸟类预计会表现出更高的繁殖力和存活率。佛罗里达灌丛鸦是联邦受威胁物种，因此，这项研究的结果可以广泛应用于帮助保护这种物种以及其他受威胁物种，为有关补充抗氧化剂饮食的最佳管理实践提供重要线索。 此外，通过与密切参与环境教育的生态研究机构阿奇博尔德生物站（ABS）合作，这项研究将把科学进步与教育机会结合起来。这项研究将发表在知名期刊上，并在科学会议和非专业会议上进行展示。它还将通过与 ABS 访客的互动进行非正式分享，并通过该站的实习计划（每年吸引数十名本科生和研究生到该站从事独立项目）和 ABS 生态教育计划（每年接待近 3,000 名三至五年级学生）正式分享。