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Multidimensional Incoherent Spectroscopy for Measuring Condensed-Phase Dynamics

用于测量凝聚相动力学的多维非相干光谱

基本信息

批准号：
1111530
负责人：
Mark Berg
金额：
$ 42.7万
依托单位：
University South Carolina Research Foundation
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-15 至 2014-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1111530&HistoricalAwards=false
关键词：
Multidimensional Incoherent Spectroscopy Measuring Condensed

项目摘要

With support from the Chemical Measurement and Imaging program in the Division of Chemistry, Prof. Mark Berg and his group at the University of South Carolina are developing and applying new methods to assess the rates of chemical processes (including peptide conformational dynamics) in heterogeneous materials. Traditional "one-dimensional" spectroscopic methods use a single excitation source and measure rates over a single time period. Prof. Berg is developing multidimensional methods that use more than one excitation source and measure rates over multiple periods. By using three excitation pulses, both the distribution and rates of conformational change will be measured. Multidimensional methods are also being broadened to include light pulses of variable polarization and thereby measure the distribution of local viscosities within bulk polymers. Kinetic measurements are used throughout chemistry, biology, physics and engineering. The fundamentally new approaches to kinetics developed in this program will provide new tools to all these areas. Training in advanced spectroscopy will be done at the University of South Carolina, which is both geographically underserved and has a large population of students from underrepresented groups. In addition, Prof. Berg is collaborating with Prof. Peter Chen of Spelman College, an HBCU for women, to adapt the technological development from this project to an undergraduate research environment.

在化学系化学测量和成像项目的支持下，南卡罗来纳大学的Mark Berg教授和他的团队正在开发和应用新的方法来评估非均质材料中的化学过程(包括多肽构象动力学)的速率。传统的“一维”光谱方法使用单一的激发源，并在单一时间段内测量速率。伯格教授正在开发多维方法，这种方法使用多个激发源，并测量多个周期的速率。通过使用三个激发脉冲，将测量构象变化的分布和速率。多维方法也在扩展，以包括可变偏振的光脉冲，从而测量本体聚合物中局部粘度的分布。动力学测量在化学、生物学、物理学和工程学中都有使用。在这个项目中开发的全新的动力学方法将为所有这些领域提供新的工具。高级光谱学方面的培训将在南卡罗来纳大学进行，该大学在地理上服务不足，而且有大量来自代表性不足群体的学生。此外，伯格教授正在与哈佛商业大学女子学院斯佩尔曼学院的陈彼得教授合作，将这个项目的技术发展适应本科生的研究环境。