Studies of New Ionization Approaches in Mass Spectrometry for Imaging

成像质谱新电离方法的研究

基本信息

  • 批准号:
    1112289
  • 负责人:
  • 金额:
    $ 34.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-07-15 至 2014-12-31
  • 项目状态:
    已结题

项目摘要

With support from the Chemical Measurement and Imaging Program, Professor Charles N. McEwen of the University of the Sciences seeks improved understanding of certain newly developed mass spectrometric (MS) ionization methods, with aims of improving reproducibility and sensitivity. These ionization methods (discovered in collaboration with Professor Sarah Trimpin of Wayne State University) have attributes of both matrix assisted laser desorption/ionization (MALDI) and electrospray ionization (ESI). They each produce multiply charged ions, similar to ESI, allowing analysis of high mass compounds and enhancing utility of ion mobility techniques. Increasing the sensitivity and reproducibility of these new ionization methods may make possible high spatial resolution imaging under atmospheric conditions. Areas requiring high throughput analyses (such as consumer protection, counter-terrorism, environmental monitoring, clinical applications, and biological materials analysis) will be impacted by these developments. The broad training gained by the graduate and undergraduate students involved will enhance their future scientific potential.
在化学测量和成像项目的支持下,科学大学的Charles N. McEwen教授寻求提高对某些新开发的质谱(MS)电离方法的理解,目的是提高再现性和灵敏度。这些电离方法(与韦恩州立大学的Sarah Trimpin教授合作发现)具有基质辅助激光解吸/电离(MALDI)和电喷雾电离(ESI)的特性。它们各自产生多个带电离子,类似于ESI,允许分析高质量化合物并增强离子迁移技术的效用。提高这些新电离方法的灵敏度和再现性可能使大气条件下的高空间分辨率成像成为可能。需要高通量分析的领域(如消费者保护、反恐、环境监测、临床应用和生物材料分析)将受到这些发展的影响。研究生和本科生所获得的广泛训练将增强他们未来的科学潜力。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Charles McEwen其他文献

Charles McEwen的其他文献

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{{ truncateString('Charles McEwen', 18)}}的其他基金

SBIR Phase I: Robust High-Throughput Mass Spectrometry Through Vacuum Matrix Assisted Ionization
SBIR 第一阶段:通过真空基质辅助电离进行稳健的高通量质谱分析
  • 批准号:
    1913787
  • 财政年份:
    2019
  • 资助金额:
    $ 34.5万
  • 项目类别:
    Standard Grant
STTR Phase II: Novel Ionization Process for Materials Characterization using Mass Spectrometry
STTR 第二阶段:使用质谱进行材料表征的新型电离过程
  • 批准号:
    1556043
  • 财政年份:
    2016
  • 资助金额:
    $ 34.5万
  • 项目类别:
    Standard Grant
STTR Phase I: Novel Ionization Process for Materials Characterization using Mass Spectrometry
STTR 第一阶段:使用质谱进行材料表征的新型电离过程
  • 批准号:
    1417124
  • 财政年份:
    2014
  • 资助金额:
    $ 34.5万
  • 项目类别:
    Standard Grant

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