Sensitive Imaging of Magnetic Nanoparticles and Aggregates by Active Feedback Magnetic Resonance

通过主动反馈磁共振对磁性纳米颗粒和聚集体进行灵敏成像

• 批准号: 1112574
• 负责人: Yung-Ya Lin
• 金额: $ 41万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1112574&HistoricalAwards=false
• 关键词: Sensitive; Imaging; Magnetic; Nanoparticles; Aggregates

With support from the Chemical Measurement and Imaging Program, Prof. Yung-Ya Lin and his group at UCLA are developing "Active-Feedback Magnetic Resonance" for sensitive imaging of magnetic nanoparticles and aggregates (e.g., ferritin and hemoglobin). The approach has two major advantages: enhanced imaging sensitivity with positive contrast and experimental robustness due to fixed-point spin dynamics. These two features provide superior sensitivity/contrast in imaging magnetic nanoparticles and aggregates, as compared to existing methods.The work will enable improvements in magnetic resonance with potential biomedical applications (molecular imaging and early disease detection). In addition, web-based materials will be developed to promote training, teaching, and learning in molecular imaging and magnetic resonance.

在化学测量和成像项目的支持下，加州大学洛杉矶分校的Yung-Ya Lin教授和他的团队正在开发“主动反馈磁共振”，用于磁性纳米颗粒和聚集体的灵敏成像（例如，铁蛋白和血红蛋白）。 该方法有两个主要优点：增强成像灵敏度与正对比度和实验鲁棒性，由于固定点自旋动力学。与现有的方法相比，这两个特征在成像磁性纳米颗粒和聚集体方面提供了上级灵敏度/对比度。这项工作将使磁共振技术的改进具有潜在的生物医学应用（分子成像和早期疾病检测）。此外，将开发基于网络的材料，以促进分子成像和磁共振方面的培训、教学和学习。