International Collaboration in Chemistry: Single-Molecule Imaging, Dynamics,and Electronics at Multivalent Host-Guest Surfaces

美国研究人员及其海外同行（ICC）国际化学合作项目专注于开发复杂的超分子组装和测量，以推进化学和纳米科学领域的最新技术。高度有序的短链环糊精单层被组装在金属衬底上。这些组件用于使用高分辨率扫描隧道显微镜（STM）的研究，以前所未有的细节了解疏水客体分子的结合。单（超）分子研究使单客体结合的电子和化学研究，以及多价结合和活性客体分子模式和偶联的直接表征成为可能。加州大学洛杉矶分校的Weiss小组得到了美国国家科学基金会化学部大分子、超分子和纳米化学项目的支持，并得到了国际科学与工程办公室的资助。特温特大学的Huskens小组得到了荷兰科学研究组织（NWO）的支持，这是一个合作的国际资助机构。分子界面识别过程是许多重要的技术和生物过程和现象的核心。这项工作旨在更深入地了解分子界面识别，这可能与太阳能转换、电子传感器和生物医学应用等领域相关。此外，已知多价性是生物系统中活性的关键组成部分，特别是对于细胞膜识别。环糊精单层作为一个很好的模型系统来解决多价性问题。这个项目具有很强的互动性和多样化的研究环境，为教学、培训和学习提供了一个环境。学生长期访问合作伙伴实验室进行合作工作和培训，为学生提供了非常宝贵的国际经验。

This International Collaboration in Chemistry between US Investigators and their Counterparts Abroad (ICC) project focuses on developing sophisticated supramolecular assemblies and measurements to advance the state of the art in this area of chemistry and nanoscience. Highly ordered cyclodextrin monolayers with short tethers are assembled on metal substrates. These assemblies are used for studies using high-resolution scanning tunneling microscopy (STM) to understand binding of hydrophobic guest molecules with unprecedented detail. Single (supra)molecular studies enable both electronic and chemical investigations of single-guest binding, as well as direct characterization of multivalent binding and active guest molecule patterning and coupling. The Weiss group at UCLA is supported by the Macromolecular, Supramolecular and Nanochemistry Program of the NSF Chemistry Division, with contribution from the Office of International Science and Engineering. The Huskens group at the University of Twente is supported by the Netherlands Organization for Scientific Research (NWO), the partnering international funding agency.The process of molecular interfacial recognition is central to many important technological and biological processes and phenomena. This work aims to gain a deeper understanding of molecular interfacial recognition which might be relevant for areas as diverse as solar energy conversion and electronics to sensors and biomedical applications. In addition, multivalency is known to be a critical component of activity in biological systems, in particular for cell membrane recognition. Cyclodextrin monolayers function as excellent model systems to address multivalency issues at such membranes. The strong interactive and diverse research environments of this project provides a setting for teaching, training and learning. The extended visits of students to partner laboratories for collaborative work and training provide students with highly valuable international experience.