MRI: Acquisition of an AB SCIEX Triple TOF5600 Spectrometer for Metabolomics Research

MRI：购买 AB SCIEX Triple TOF5600 光谱仪用于代谢组学研究

• 批准号: 1126373
• 负责人: James Ferry
• 金额: $ 36.96万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1126373&HistoricalAwards=false
• 关键词: MRI; Acquisition; AB; SCIEX; Triple

1126373FerryMass spectrometry (MS) is one of the leading analytical tools exploited by the metabolomics community. Despite technological advances, it remains impossible for a single piece of MS instrumentation to provide all of the information sought in global analyses. As such, all of the centers of excellence in metabolomics utilize pipelines that exploit multiple analytical platforms (e.g., LC-MS, GCEI-MS, GC-CI-MS). The proposed AB Sciex TripleTOFTM 5600 is a high resolution, exact mass MS/MS platform that is specifically designed to provide the resolving power sought by the metabolomics community. This instrument provides a mass resolution of up to 40,000 full width at half height (FWHH) in both positive and negative ion modes, exact mass (1 ppm RMS) with a dynamic range of up to five orders of magnitude, a rapid acquisition rate (20 Hz) that fully exploits the resolving power of UPLC, and absolute sensitivity more usually associated with triple quadrupole instruments operating in Selected Reaction Monitoring (SRM) mode. In short, this instrument offers speed, accuracy and versatility to explore complex samples from a large user group with diverse needs.

1126373 FerryMass Spectrometry（MS）是代谢组学领域开发的领先分析工具之一。尽管技术进步，它仍然是不可能的一个单一的MS仪器提供所有的信息，在全球分析中寻求。因此，代谢组学中的所有卓越中心都利用利用多个分析平台（例如，LC-MS、GCEI-MS、GC-CI-MS）。申报的AB Sciex TripleTOFTM 5600是一种高分辨率、精确质量的MS/MS平台，专门设计用于提供代谢组学团体所寻求的分辨率。该仪器在正离子和负离子模式下的质量分辨率高达40，000半高全宽（FWHH），精确质量（1 ppm RMS），动态范围高达五个数量级，快速采集速率（20 Hz），充分利用了UPLC的分辨率，和绝对灵敏度更通常与在选择反应监测（SRM）模式下操作的三重四极杆仪器相关联。简而言之，该仪器提供了速度，准确性和多功能性，以探索具有不同需求的大型用户群的复杂样品。