MRI: Acquisition of an AB SCIEX Triple TOF5600 Spectrometer for Metabolomics Research

1126373ferry质谱分析（MS）是代谢组学领域的主要分析工具之一。尽管技术进步了，但单台质谱仪器仍然不可能提供全球分析所需的所有信息。因此，代谢组学的所有卓越中心都利用利用多种分析平台的管道（例如，LC-MS, GCEI-MS, GC-CI-MS）。提出的AB Sciex TripleTOFTM 5600是一个高分辨率，精确质量的MS/MS平台，专门设计用于提供代谢组学社区所寻求的分辨率。该仪器在正离子和负离子模式下提供高达40,000全宽半高（FWHH）的质量分辨率，精确质量（1 ppm RMS），动态范围高达五个数量级，快速采集速率（20 Hz），充分利用UPLC的分辨率，以及通常与在选择反应监测（SRM）模式下工作的三重四极杆仪器相关的绝对灵敏度。简而言之，该仪器提供了速度，准确性和多功能性，以探索具有不同需求的大型用户群体的复杂样品。

1126373FerryMass spectrometry (MS) is one of the leading analytical tools exploited by the metabolomics community. Despite technological advances, it remains impossible for a single piece of MS instrumentation to provide all of the information sought in global analyses. As such, all of the centers of excellence in metabolomics utilize pipelines that exploit multiple analytical platforms (e.g., LC-MS, GCEI-MS, GC-CI-MS). The proposed AB Sciex TripleTOFTM 5600 is a high resolution, exact mass MS/MS platform that is specifically designed to provide the resolving power sought by the metabolomics community. This instrument provides a mass resolution of up to 40,000 full width at half height (FWHH) in both positive and negative ion modes, exact mass (1 ppm RMS) with a dynamic range of up to five orders of magnitude, a rapid acquisition rate (20 Hz) that fully exploits the resolving power of UPLC, and absolute sensitivity more usually associated with triple quadrupole instruments operating in Selected Reaction Monitoring (SRM) mode. In short, this instrument offers speed, accuracy and versatility to explore complex samples from a large user group with diverse needs.