Preparation and Utilization of SF5-Containing Building Blocks

氟有机化合物的化学是生命科学中发展最快的领域之一，尽管氟对生命的生物有机化学几乎是“陌生的”。在有机分子中引入氟通常会导致其物理、化学和生物性质的显著变化。在所有含氟分子中，五氟硫(SF5)取代的氟分子占有特殊的位置。由于其高电负性、显著的立体效应、显著的疏水性和高的耐化学性，该基团最近被贴上了“未来的取代基”的标签。这是一个由两个高度专业化的实验室在无机或有机氟化学领域进行的国际合作，旨在推动新兴的SF5化学领域的变革性研究，而不是单一实验室的增量研究。这一合作最近在没有得到支持的情况下启动，已经产生了两次科学报告和一次手稿提交。拟议活动的智力优势包括开发新的合成路线来构建关键的含SF5的积木和亲电的SF5CF2+来源，并利用它们将含SF5的基团引入复杂的有机结构，合成具有医学意义的化合物，并研究它们的生物活性和专一性。还将制备更多的含SF5的新型材料，并研究它们在绿色化学、含能材料和聚合物领域的应用。

The chemistry of fluoroorganic compounds is one of the most rapidly developing areas in the life sciences, despite the fact that fluorine is virtually “foreign” to the bioorganic chemistry of life. The introduction of fluorine into organic molecules generally leads to significant changes in their physical, chemical, and biological properties. Among all fluorine-containing molecules, pentafluorosulfanyl(SF5)- substituted ones occupy a special place. Because of its high electronegativity, substantial steric effect, significant hydrophobicity, and high chemical resistance, this group has recently been labeled as the “substituent of the future.” An international collaboration of two highly specialized laboratories in the area of inorganic or organic fluorine chemistry, seeks to advance transformative research in the emerging field of SF5 chemistry versus the incremental research characteristic of a single laboratory. This collaboration, recently initiated without support, has already resulted in two scientific presentations and one manuscript submission. The intellectual merit of the proposed activity involves developing new synthetic routes to key SF5-containing building blocks and electrophilic SF5CF2+ sources, and using them to introduce SF5-containing groups into complex organic structures, synthesizing medicinally relevant compounds, and investigating their biological activity and specificity. Additional novel SF5-containing materials will be prepared and their suitability for applications in green chemistry, energetic materials, and polymer fields will be investigated.