CAREER: Substrate-Directed C-H Borylation Reactions

职业：底物导向的 C-H 硼化反应

• 批准号: 1151092
• 负责人: Timothy Clark
• 金额: $ 40万
• 依托单位: University of San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1151092&HistoricalAwards=false
• 关键词: CAREER; Substrate; Directed; Borylation; Reactions

This CAREER award, funded by the Chemical Catalysis Program of the Chemistry Division, supports the proposed research and educational plans of Professor Timothy B. Clark of the Department of Chemistry and Biochemistry at the University of San Diego. The project aims to develop substrate-directed C-H borylation reactions, which result in selective formation of carbon-boron bonds. The proposed research plan focuses on the design and development of catalysts that selectively functionalize C-H bonds into C-B bonds. Ultimately, the catalysts will be modified to be used in the C-H borylation of non-aromatic substrates, providing valuable intermediates in organic synthesis.The carbon-boron bond is versatile and can be used to access a number of functional groups that are common in biologically relevant compounds such as pharmaceuticals. This work will simplify access to a variety of derivatives and could be used to facilitate the discovery of new materials for diabetes testing. The bulk of the research performed will be carried out by undergraduate students, providing valuable experiences for students interested in pursuing careers in the area of catalysis or related fields. The proposed educational activity aims to introduce high school students to applications and careers in chemistry through providing an authentic research experience for high school teachers and subsequently engaging their students in various activities such as visiting USD Science building and field trip to local chemical R&D facility. The involvement of high school teachers in an authentic research experience will also allow them to incorporate research concepts into their curriculum.

这个职业奖，由化学系的化学催化计划资助，支持蒂莫西教授B的拟议研究和教育计划。圣地亚哥大学化学与生物化学系的克拉克。该项目旨在开发底物导向的C-H硼基化反应，从而选择性地形成碳-硼键。拟议的研究计划侧重于设计和开发催化剂，选择性地将C-H键官能化为C-B键。最终，这些催化剂将被改性用于非芳香族底物的C-H硼基化反应，为有机合成提供有价值的中间体。碳-硼键用途广泛，可用于获得许多生物相关化合物（如药物）中常见的官能团。这项工作将简化获得各种衍生物的过程，并可用于促进糖尿病检测新材料的发现。大部分研究将由本科生进行，为有兴趣在催化或相关领域从事职业的学生提供宝贵的经验。建议的教育活动旨在通过为高中教师提供真实的研究经验，并随后让学生参与各种活动，例如参观USD科学大楼和实地考察当地的化学研发设施，向高中学生介绍化学应用和职业。 高中教师参与真实的研究经验也将使他们能够将研究概念纳入他们的课程。