CAREER: Substrate-Directed C-H Borylation Reactions

这项职业奖由化学部化学催化计划资助，支持圣地亚哥大学化学和生物化学系蒂莫西·B·克拉克教授提出的研究和教育计划。该项目旨在开发底物导向的C-H硼化反应，该反应导致选择性地形成碳-硼键。拟议的研究计划侧重于设计和开发选择性地将C-H键官能化为C-B键的催化剂。最终，这些催化剂将被改进，用于非芳香族底物的C-H硼化反应，在有机合成中提供有价值的中间体。碳-硼键用途广泛，可用于访问一些在生物相关化合物(如药物)中常见的官能团。这项工作将简化各种衍生品的获取，并可用于促进糖尿病测试新材料的发现。大部分研究将由本科生进行，为有意从事催化或相关领域职业生涯的学生提供宝贵的经验。拟议的教育活动旨在通过为高中教师提供真实的研究体验，并随后让他们的学生参与各种活动，如参观加州大学科学大楼和实地考察当地的化学研发设施，向高中生介绍化学应用和职业生涯。高中教师参与真实的研究体验也将使他们能够将研究概念纳入他们的课程。

This CAREER award, funded by the Chemical Catalysis Program of the Chemistry Division, supports the proposed research and educational plans of Professor Timothy B. Clark of the Department of Chemistry and Biochemistry at the University of San Diego. The project aims to develop substrate-directed C-H borylation reactions, which result in selective formation of carbon-boron bonds. The proposed research plan focuses on the design and development of catalysts that selectively functionalize C-H bonds into C-B bonds. Ultimately, the catalysts will be modified to be used in the C-H borylation of non-aromatic substrates, providing valuable intermediates in organic synthesis.The carbon-boron bond is versatile and can be used to access a number of functional groups that are common in biologically relevant compounds such as pharmaceuticals. This work will simplify access to a variety of derivatives and could be used to facilitate the discovery of new materials for diabetes testing. The bulk of the research performed will be carried out by undergraduate students, providing valuable experiences for students interested in pursuing careers in the area of catalysis or related fields. The proposed educational activity aims to introduce high school students to applications and careers in chemistry through providing an authentic research experience for high school teachers and subsequently engaging their students in various activities such as visiting USD Science building and field trip to local chemical R&D facility. The involvement of high school teachers in an authentic research experience will also allow them to incorporate research concepts into their curriculum.