CAREER: Synthetic auxotrophy for the containment of engineered microbes

职业:用于遏制工程微生物的合成营养缺陷型

基本信息

  • 批准号:
    1151220
  • 负责人:
  • 金额:
    $ 48.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-03-01 至 2017-02-28
  • 项目状态:
    已结题

项目摘要

CBET 1151220/ AndersonThis NSF CAREER award by the Biotechnology, Biochemical and Biomass Engineering program supports the development of a novel containment strategy for engineered organisms based on synthetic auxotrophy. Synthetic auxotrophs provide a strategy for mitigating the risks of accidental environmental release of novel organisms developed using the tools of synthetic biology. The synthetic auxotrophs developed in this study will be engineered such that their viability is dependent upon a chemical not found in nature. Therefore these organisms cannot survive outside the contained environments to which the synthetic compound has been added. The process for generating these synthetic auxotrophs involves a novel protein engineering strategy. It takes a protein critical to the growth of the organism encoded by an essential gene and rewires its interactions with the cell such that it can only grows in the presence of the synthetic compound. Along with the development of containment strategies, the PI will develop an interactive website that provides context and navigation through the diverse training resources available on the internet. Based around the idea of a Trail, or a series of related electronic content, the site will guide students through tutorials, quizzes, and multimedia content towards mastery of specific subject areas. These subjects include the technical implementation of synthetic biology, as well as design theory, basic science, and issues of human practice. Together these efforts address key unresolved issues of biosafety and training in this field.
CBET 1151220/Anderson生物技术、生物化学和生物质工程项目的NSF CAREER奖支持开发一种基于合成营养缺陷型的工程生物新的遏制策略。合成营养缺陷型提供了一种策略,用于减轻使用合成生物学工具开发的新生物体意外环境释放的风险。在这项研究中开发的合成营养缺陷型将被改造,使其生存能力取决于一种化学物质,而不是在自然界中发现。因此,这些生物体不能在添加了合成化合物的封闭环境之外存活。产生这些合成营养缺陷型的过程涉及一种新的蛋白质工程策略。它需要一种由必需基因编码的对生物体生长至关重要的蛋白质,并重新连接其与细胞的相互作用,使其只能在合成化合物存在的情况下生长。 沿着遏制战略的发展,PI将开发一个互动网站,通过互联网上的各种培训资源提供背景和导航。 基于Trail或一系列相关电子内容的想法,该网站将引导学生通过教程,测验和多媒体内容掌握特定学科领域。这些科目包括合成生物学的技术实现,以及设计理论,基础科学和人类实践问题。 这些努力共同解决生物安全和这一领域培训方面尚未解决的关键问题。

项目成果

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John Anderson其他文献

Multi-localized time-symmetric initial data for the Einstein vacuum equations
爱因斯坦真空方程的多局域时间对称初始数据
MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment.
神经母细胞瘤血流动力学脉管系统的 MRI 成像可预测抗血管生成治疗的反应。
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    11.2
  • 作者:
    K. Zormpas;N. Jerome;M. Blackledge;F. Carceller;E. Poon;M. Clarke;C. McErlean;G. Barone;A. Koers;S. Vaidya;L. Marshall;A. Pearson;L. Moreno;John Anderson;N. Sebire;K. McHugh;D. Koh;Yinyin Yuan;L. Chesler;S. Robinson;Y. Jamin
  • 通讯作者:
    Y. Jamin
MYCN deregulation as a potential target for novel therapies in rhabdomyosarcoma
MYCN 放松管制作为横纹肌肉瘤新疗法的潜在目标
  • DOI:
    10.1586/14737140.6.2.217
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    D. Morgenstern;John Anderson
  • 通讯作者:
    John Anderson
Noninvasive MRI Native T1 Mapping Detects Response to MYCN-targeted Therapies in the Th-MYCN Model of Neuroblastoma
无创 MRI 天然 T1 定位检测神经母细胞瘤 Th-MYCN 模型对 MYCN 靶向治疗的反应
  • DOI:
    10.1158/0008-5472.can-20-0133
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    11.2
  • 作者:
    K. Zormpas;E. Poon;M. Clarke;N. Jerome;J. Boult;M. Blackledge;F. Carceller;A. Koers;G. Barone;A. Pearson;L. Moreno;John Anderson;N. Sebire;K. McHugh;D. Koh;L. Chesler;Yinyin Yuan;S. Robinson;Y. Jamin
  • 通讯作者:
    Y. Jamin
The Value and Necessity of Natural History Studies of Waterbirds
水鸟自然历史研究的价值和必要性
  • DOI:
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    B. Marcot;D. Gawlik;A. Yanosky;John Anderson;Ankita Gupta;K. Sundar
  • 通讯作者:
    K. Sundar

John Anderson的其他文献

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{{ truncateString('John Anderson', 18)}}的其他基金

Synthetic control over redox-state and morphology in electronically complex coordination polymers
电子复杂配位聚合物中氧化还原态和形态的合成控制
  • 批准号:
    2315924
  • 财政年份:
    2023
  • 资助金额:
    $ 48.88万
  • 项目类别:
    Standard Grant
PostDoctoral Research Fellowship
博士后研究奖学金
  • 批准号:
    2103266
  • 财政年份:
    2021
  • 资助金额:
    $ 48.88万
  • 项目类别:
    Fellowship Award
Modular Transition Metal Chalcogenide Coordination Polymers
模块化过渡金属硫属化物配位聚合物
  • 批准号:
    2002367
  • 财政年份:
    2020
  • 资助金额:
    $ 48.88万
  • 项目类别:
    Continuing Grant
WOWCLAN People: Workshop on Water, Culture, Language, and Native People in the Arctic
WOWCLAN People:北极水、文化、语言和原住民研讨会
  • 批准号:
    2013929
  • 财政年份:
    2020
  • 资助金额:
    $ 48.88万
  • 项目类别:
    Standard Grant
CAREER: Probing Catalytic O-O Bond Formation with Psuedo-Tetrahedral Terminal Oxo Complexes
职业:利用准四面体末端氧配合物探测催化 O-O 键的形成
  • 批准号:
    1654144
  • 财政年份:
    2017
  • 资助金额:
    $ 48.88万
  • 项目类别:
    Continuing Grant
Using Neural Imaging and Computational Modeling to Understand how Visuo-Spatial Processes Facilitate Mathematical Symbolization and Transfer
使用神经成像和计算模型来了解视觉空间过程如何促进数学符号化和传输
  • 批准号:
    1420008
  • 财政年份:
    2014
  • 资助金额:
    $ 48.88万
  • 项目类别:
    Standard Grant
Evidence for Paleo Ice Stream Collapse in the Western Ross Sea since the Last Glacial Maximum.
自末次盛冰期以来西罗斯海古冰流崩塌的证据。
  • 批准号:
    1246353
  • 财政年份:
    2013
  • 资助金额:
    $ 48.88万
  • 项目类别:
    Standard Grant
Collaborative Research: ABI Development: A Modular, Community Based Design Platform for Synthetic Biology (Clotho)
合作研究:ABI 开发:基于社区的模块化合成生物学设计平台 (Clotho)
  • 批准号:
    1147207
  • 财政年份:
    2012
  • 资助金额:
    $ 48.88万
  • 项目类别:
    Continuing Grant
The Extension of Mathematical Knowledge: A Cognitive and Neuroscience Investigation
数学知识的扩展:认知和神经科学研究
  • 批准号:
    1007945
  • 财政年份:
    2010
  • 资助金额:
    $ 48.88万
  • 项目类别:
    Continuing Grant
History of, and Mechanisms Leading to, Post-LGM Retreat of the West Antarctic
末次盛宴后南极西部撤退的历史和机制
  • 批准号:
    0837925
  • 财政年份:
    2009
  • 资助金额:
    $ 48.88万
  • 项目类别:
    Standard Grant

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Building Synthetic Biofilm Consortia for Polyfluorinated Chemicals Biodegradation
建立多氟化学品生物降解合成生物膜联盟
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