CAREER: Total Synthesis of Complex Alkaloid Natural Products

美国国家科学基金会化学合成计划支持Seth B. Herzon教授在复杂生物碱全合成领域的工作。该建议建立在先前研究的基础上，为合成hasubanan生物碱提供了有效的策略，hasubanan生物碱是一大类植物性天然产物。在本文中，我们将继续研究这些策略在合成更复杂的生物碱天然产物中的应用。与此同时，将探索受合成研究启发的新合成方法的发展。开发有效的合成哈苏巴南生物碱的方法将改善具有多种生物效应的分子的获取途径。这项研究将为学生在复杂的有机合成方面提供培训，为他们在学术界或制药行业的职业生涯做好准备。二年级有机化学新教学方法的适应和系统的、研究性的本科教学是本项目的另一个重要组成部分。目标是通过改进本科有机化学的教学和学习方式，增加追求化学和相关研究领域的学生（包括代表性不足的群体的学生）的数量。此外，还计划在大学范围内开展一项为高中生提供化学实践经验的项目。

The Chemical Synthesis Program of the National Science Foundation supports the work of Professor Seth B. Herzon in the area of complex alkaloid total synthesis. The proposal builds on prior research which provided efficient strategies to synthesize the hasubanan alkaloids, a large family of botanical natural products. In the proposed work, the application of these strategies toward the synthesis of more complex alkaloid natural products will be pursued. In parallel, the development of new synthetic methods, inspired by the synthetic studies, will be explored.The development of efficient methods for the synthesis of hasubanan alkaloids will improve access to molecules with diverse biological effects. This research will provide training for students in sophisticated organic synthesis preparing them for a career in academia or pharmaceutical industry. The adaptation of new teaching methods for sophomore organic chemistry and a systematic, research-based approach to undergraduate education is another important component of this project. The goal is to increase the number of students (including students of underrepresented groups) pursuing chemistry and related fields of study by improving the way undergraduate organic chemistry is taught, and learned. A University-wide program to provide high school students with hands-on experience in chemistry is also planned.