CAREER: Total Synthesis of Complex Alkaloid Natural Products

职业：复杂生物碱天然产物的全合成

• 批准号: 1151563
• 负责人: Seth Herzon
• 金额: $ 55万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1151563&HistoricalAwards=false
• 关键词: CAREER; Total; Synthesis; Complex; Alkaloid

The Chemical Synthesis Program of the National Science Foundation supports the work of Professor Seth B. Herzon in the area of complex alkaloid total synthesis. The proposal builds on prior research which provided efficient strategies to synthesize the hasubanan alkaloids, a large family of botanical natural products. In the proposed work, the application of these strategies toward the synthesis of more complex alkaloid natural products will be pursued. In parallel, the development of new synthetic methods, inspired by the synthetic studies, will be explored.The development of efficient methods for the synthesis of hasubanan alkaloids will improve access to molecules with diverse biological effects. This research will provide training for students in sophisticated organic synthesis preparing them for a career in academia or pharmaceutical industry. The adaptation of new teaching methods for sophomore organic chemistry and a systematic, research-based approach to undergraduate education is another important component of this project. The goal is to increase the number of students (including students of underrepresented groups) pursuing chemistry and related fields of study by improving the way undergraduate organic chemistry is taught, and learned. A University-wide program to provide high school students with hands-on experience in chemistry is also planned.

美国国家科学基金会的化学合成计划支持Seth B教授的工作。Herzon在复杂生物碱全合成领域的贡献。 该提案建立在先前的研究基础上，这些研究提供了合成hasubanan生物碱的有效策略，hasubanan生物碱是一个大家族的植物天然产物。 在拟议的工作中，这些策略的应用对更复杂的生物碱天然产物的合成将继续进行。 与此同时，受合成研究的启发，将探索新的合成方法的发展。有效合成hasubanan生物碱的方法的发展将改善具有不同生物效应的分子的获得。 这项研究将为学生提供复杂的有机合成培训，为他们在学术界或制药业的职业生涯做好准备。 大二有机化学新的教学方法和系统的，以研究为基础的本科教育的适应是这个项目的另一个重要组成部分。 目标是通过改善本科有机化学的教学和学习方式，增加追求化学和相关研究领域的学生（包括代表性不足的群体的学生）的数量。 一个为高中生提供化学实践经验的大学范围内的项目也在计划中。