CAREER: Catalytic Methods in Functionalizing Single Bonds to Carbon

职业：碳单键功能化的催化方法

• 批准号: 1151547
• 负责人: Christopher Douglas
• 金额: $ 40万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1151547&HistoricalAwards=false
• 关键词: CAREER; Catalytic; Methods; Functionalizing; Single

With this CAREER Award, the Chemical Synthesis program is supporting the research of Professor Douglas of the University of Minnesota - Twin Cities for studies toward the activation and functionalization of carbon sigma bonds adjacent to carbonyls. First, new methods involving the metal-promoted activation of these bonds in ketones, esters, and aldehydes will be developed. A major focus will be on the insertion of unsaturated groups into the activated bonds. Second, mechanistic work will be undertaken to develop a deeper understanding of the new reactivity develop. Cross-over and kinetic isotope effect experiments will teach us how the reactions proceed and give insight in to the development of improved catalyst systems and asymmetric processes. Finally the methods developed under this award will be applied to a diverse set of synthesis challenges. Applications will range from the synthesis of commodity chemical feedstocks like methyl ethyl ketone to the synthesis of complex natural products like dragmacidin E.Professor Douglas will also initiate two educational projects that interweave research and teaching. The first project involves discovery-based learning in the large chemistry classroom. A hybrid, guided-inquiry and traditional-lecture teaching plan for introductory organic chemistry will be piloted and tested against appropriate control groups. The second program is an outreach program involving a local recording-arts high school that serves at-risk children from predominantly underrepresented groups.

化学合成项目获得了CAREER奖，支持明尼苏达大学双城分校的Douglas教授的研究，研究与羰基相邻的碳sigma键的活化和功能化。首先，将开发涉及金属促进酮、酯和醛中这些键的激活的新方法。一个主要的焦点将是在活化的键中插入不饱和基团。其次，将进行机械工作，以加深对新反应性发展的理解。交叉和动力学同位素效应实验将告诉我们反应是如何进行的，并为改进催化剂系统和不对称过程的发展提供见解。最后，根据该奖项开发的方法将应用于各种合成挑战。应用范围将从合成商品化学原料如甲基乙基酮到合成复杂的天然产物如德拉马西丁e .道格拉斯教授还将启动两个将研究和教学相结合的教育项目。第一个项目涉及在大型化学教室中进行基于发现的学习。有机化学入门课程将采用一种混合式、引导探究式和传统讲座式的教学计划，在适当的对照组中进行试点和测试。第二个项目是一个外联项目，涉及一所当地的录音艺术高中，该高中为来自弱势群体的高危儿童提供服务。