CAREER: Functional Metal-Ligand Assemblies: Self-Sorting, Supramolecular Catalysis and Molecular Dynamics

职业：功能金属配体组装：自排序、超分子催化和分子动力学

• 批准号: 1151773
• 负责人: Richard Hooley
• 金额: $ 60万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1151773&HistoricalAwards=false
• 关键词: CAREER; Functional; Metal; Ligand; Assemblies

The Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division supports the research group of Dr. Richard Hooley of the University of California-Riverside to create new water-soluble functional synthetic receptors via metal-ligand based self-assembly and investigate their application towards molecular recognition and supramolecular catalysis. This research aims to address one of the main deficiencies faced by current synthetic receptors when compared to enzymes; the inability to present a functional group towards a guest bound on the interior of the cavity. The synthetic route to the metal-ligand clusters is modular and easily tunable, allowing access to a wide scope of introverted groups. By orienting functional groups towards the bound guest, selective substrate recognition and supramolecular catalysis will be enhanced. The presence of chiral species, hydrogen bond donors or nucleophiles on the interior of the clusters allows a number of novel receptor properties to be studied. In addition, by positioning catalytically active groups in close proximity with bound substrates, biomimetic reactions and catalysis are possible. NMR spectroscopy will be used to investigate guest binding, ligand exchange and reaction kinetics.This research will extend the capabilities of synthetic host molecules in a number of fields including molecular recognition and catalysis and will introduce new avenues of research in biomimetic organic chemistry. This interdisciplinary project will offer a stimulating research environment for the education and training of students, including members of underrepresented groups. In addition, this research is integrated with an educational component that aims at increasing retention of undergraduate students (and especially underrepresented minorities) in STEM fields by engaging students through the use of collaborative problem-based case studies in the lower division organic chemistry course sequence.

化学部的大分子，超分子和纳米化学计划支持加州大学河滨分校的Richard Hooley博士的研究小组通过基于金属配体的自组装来创建新的水溶性功能合成受体，并研究其在分子识别和超分子催化方面的应用。 这项研究旨在解决目前合成受体与酶相比所面临的主要缺陷之一;无法向空腔内部结合的客体呈现官能团。 金属配体簇的合成路线是模块化的，易于调节，允许进入广泛的内向群体。 通过使官能团朝向结合的客体，将增强选择性底物识别和超分子催化。手性物种，氢键供体或亲核试剂的存在下，内部的集群允许一些新的受体性质进行研究。 此外，通过将催化活性基团定位在与结合的基底紧密接近的位置，仿生反应和催化是可能的。 核磁共振波谱将被用于研究客体结合、配体交换和反应动力学。这项研究将扩展合成主体分子在包括分子识别和催化在内的许多领域的能力，并将为仿生有机化学的研究开辟新的途径。 这一跨学科项目将为学生的教育和培训提供一个激励性的研究环境，包括代表性不足群体的成员。此外，这项研究与教育组成部分相结合，旨在通过在低年级有机化学课程序列中使用基于协作问题的案例研究来吸引学生，从而提高本科生（尤其是代表性不足的少数民族）在STEM领域的保留率。