Efficient Reactions - Selective Cu(I) Catalysts

在这个由化学部化学合成项目资助的项目中，佛罗里达州立大学化学和生物化学系的D. Tyler McQuade教授将通过创建(1)立体会聚的烯丙基取代来开发新的合成方法，为顺式和反式底物提供相同的立体异构体；(2)催化剂控制的反应活性，其中邻近的立体中心对非对映选择性的影响有限；(3)区域控制催化硼化反应。随着稀有金属（如铑和铱）变得越来越昂贵，增加廉价金属（如铜）可以进行的反应范围至关重要。由此产生的方法可能比之前的反应更有效，更有选择性，并且可以采用新的策略，从更便宜的金属中构建有价值的复杂分子，为提高可持续性提供必要的基础科学。预计这项工作不仅会导致对催化剂的更彻底的了解，提供更好的化学控制，而且还会创造有前途的新合成方法。这项工作的成功成果将对制药、农化和特种化工行业产生积极影响。此外，该项目将为学生提供优秀的培训，从本科生到博士后，包括那些来自历史上在科学领域代表性不足的群体。这些学生将成为先锋，引领未来更环保、更具国际竞争力的有机化学。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor D. Tyler McQuade of the Department of Chemistry and Biochemistry at Florida State University will develop new synthetic methods by creating (1) stereoconvergent allylic substitutions, providing the same stereoisomer for both cis and trans substrates; (2) catalyst-controlled reactivity where neighboring stereocenters have limited impact on diastereoselectivity; and (3) regiocontrolled catalytic hydroborations. As rare metals such as rhodium and iridium become more expensive, it is critically important to increase the range of reactions that can be performed by inexpensive metals such as copper. The resulting methods could be more efficient and selective than prior reactions and could enable new strategies to construct valuable complex molecules from less expensive metals, providing the basic science necessary to improve sustainability. The proposed work is predicted to result in not only a more thorough understanding of catalysts that provide greater chemical control but also the creation of promising new synthetic methods. The successful results of this work will positively impact the pharmaceutical, agrochemical and specialty chemical industries. In addition, this project will provide excellent training of students, from undergraduate to post-doctoral, including those from groups historically underrepresented in the sciences. These students will become the vanguard, leading the way into a future of more environmentally-friendly and internationally-competitive organic chemistry.