Macromolecular Nano-Carriers from Star Polymers produced via RAFT Polymerization

可逆加成断裂链转移（RAFT）聚合将用于形成具有控制分子量，窄多分散性和预定微观结构的星形聚合物。将设计和测试新的多功能星形RAFT剂，以获得具有高微观结构均匀性的星形聚合物。受控RAFT星形聚合导致星形同族共聚物和星形嵌段共聚物的机理将被研究，特别是关注线性和星形聚合物线圈的相互渗透，这是整个过程的关键步骤。实验研究将通过使用蒙特卡罗模拟技术对星型聚合进行建模来支持。随后，星形聚合物材料将被用作定制聚合物纳米载体的模板，用于通过相反极性的介质运输试剂。将构造两亲星型嵌段共聚物，使得星型聚合物的外层球体可以形成交联的壳，而内部区域包含与壳极性相反的聚合臂。去除中心核心部分后，将得到一个内部有悬垂聚合物链的纳米胶囊，内部区域和胶囊的整体尺寸都可以通过可控的聚合过程来调节。我们将详细研究这些核壳结构的分子摄取特性。

Reversible Addition Fragmentation Chain Transfer (RAFT) Polymerization will be utilized for the formation of star polymers with controlled molecular weights, narrow polydispersities, and predetermined microstructures. New plurifunctional star shaped RAFT agents will be designed and tested in order to arrive at star polymers with high microstructural homogeneity. Controlled RAFT star polymerizations leading to star homo and star block copolymers will be studied with respect to their mechanism especially focusing on the interpenetration of linear and star polymeric coils, which is a crucial step for the overall process. The experimental studies will be supported by modeling of the star polymerizations using Monte Carlo simulation techniques. The star polymeric material will subsequently be employed as template for tailored polymeric nano carriers for the transportation of agents through media of opposite polarity. Amphiphilic star block copolymers will be constructed such that the outer sphere of the star polymer may form a crosslinked shell and that the inner region contains polymeric arms with opposite polarity to the shell. After removal of the central core moiety, a nano capsule with dangling polymeric chains inside will be obtained, with both the inner region and the overall capsule size being tunable via the controlled polymerization process. The molecular uptake characteristics of these core shell structures will be studied in detail.