Polyion complex micelles as smart nano-sized drug carriers for proteins
Polyion complex micelles as smart nano-sized drug carriers for proteins
批准号:
DP140100240
负责人:
Prof Martina Stenzel
金额:
$27.25万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-21
中文摘要
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英文摘要
Novel treatments against diseases are often based on proteins, which are unstable against hydrolysis and sometimes difficult to deliver across the cell membrane. The aim of the project is to create a smart drug carrier that can encapsulate proteins efficiently. A range of block copolymers will be synthesised that are able to condense a positively charged protein resulting in the formation of polyion complex micelles. The polymer structure will be fine-tuned to create a drug carrier that releases the protein efficiently once inside mammalian cells. The outcome will be the enhanced understanding of the relationship between polymer structure and the activity of the protein and ultimately the design of an advanced and smart drug carrier.
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