Polyion complex micelles as smart nano-sized drug carriers for proteins

聚离子复合胶束作为蛋白质的智能纳米药物载体

• 批准号: DP140100240
• 负责人: Prof Martina Stenzel
• 金额: $ 27.25万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-21
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140100240
• 关键词: Polyion; complex; micelles; smart; nano

Novel treatments against diseases are often based on proteins, which are unstable against hydrolysis and sometimes difficult to deliver across the cell membrane. The aim of the project is to create a smart drug carrier that can encapsulate proteins efficiently. A range of block copolymers will be synthesised that are able to condense a positively charged protein resulting in the formation of polyion complex micelles. The polymer structure will be fine-tuned to create a drug carrier that releases the protein efficiently once inside mammalian cells. The outcome will be the enhanced understanding of the relationship between polymer structure and the activity of the protein and ultimately the design of an advanced and smart drug carrier.

针对疾病的新型治疗方法通常基于蛋白质，这些蛋白质对水解不稳定，有时难以穿过细胞膜。该项目的目的是创造一种智能药物载体，可以有效地封装蛋白质。将合成一系列嵌段共聚物，其能够缩合带正电荷的蛋白质，从而形成聚离子复合物胶束。聚合物结构将被微调，以创造一种药物载体，一旦进入哺乳动物细胞，就能有效地释放蛋白质。其结果将是增强对聚合物结构与蛋白质活性之间关系的理解，并最终设计出先进和智能的药物载体。