Highly Convergent and Stereoselective Synthesis of Heterodimeric Polycyclic Alkaloids

异二聚多环生物碱的高度收敛和立体选择性合成

基本信息

批准号：
1212527
负责人：
Mohammad Movassaghi
金额：
$ 37.5万
依托单位：
Massachusetts Institute of Technology
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1212527&HistoricalAwards=false
关键词：
Highly Convergent Stereoselective Synthesis Heterodimeric

项目摘要

With this award, the Chemical Synthesis Program of the Chemistry Division is funding Professor Mohammad Movassaghi of the Department of Chemistry at the Massachusetts Institute of Technology to explore and develop new general methodology for the formation of challenging C-C bonds by directed radical combination reactions. This project focuses on the development of mild conditions for synthesis of diazenes as intermediates in guided advanced fragment assembly. An integral part of the study will focus on evaluating and broadening the chemistry of these intermediates in chemical synthesis. The proposed study includes a thorough development of our preliminary results supported by additional mechanistic probes and studies that will provide important insight into the stereochemical course of these diazene-based assemblies for preparation of complex heterodimeric polycyclic alkaloids.Such chemistry will provide precedence of a general strategy in controlled complex chemical synthesis that will have broad impact in pharmaceutical, agricultural, and fine-chemical industries where designed complex molecules are used in biological and chemical research endeavors. The broader impacts involve training graduate students and postdoctoral researchers, broadening participation through the inclusion of undergraduate and visiting student researchers on the project, and continued contribution by the research group to MIT's Chemistry Outreach Program at local high schools.

通过该奖项，化学部的化学综合计划是马萨诸塞州技术研究所化学系的穆罕默德·马达萨吉教授的资助，旨在探索和开发新的通用方法，以通过有名自由基组合反应形成挑战性的C-C债券。该项目的重点是在带导的晚期片段组装中中间体合成的轻度条件。该研究的组成部分将重点介绍化学合成中这些中间体的化学性质。 The proposed study includes a thorough development of our preliminary results supported by additional mechanistic probes and studies that will provide important insight into the stereochemical course of these diazene-based assemblies for preparation of complex heterodimeric polycyclic alkaloids.Such chemistry will provide precedence of a general strategy in controlled complex chemical synthesis that will have broad impact in pharmaceutical, agricultural, and fine-chemical industries where designed complex分子用于生物学和化学研究努力。更广泛的影响涉及培训研究生和博士后研究人员，通过纳入本科生和来访的学生研究人员来扩大参与，并继续研究小组对MIT当地高中的MIT化学外展计划的贡献。