Light-directed derivatization, caging, and releasing methodologies based on o-quinone methide chemistry
基于邻醌甲基化物化学的光引导衍生化、笼蔽和释放方法
基本信息
- 批准号:1213789
- 负责人:
- 金额:$ 42.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2015-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With this award, the Chemical Synthesis Program of the Chemistry Division is funding Professor Vladimir Popik of the Department of Chemistry at the University of Georgia to design and synthesize novel UV and NIR-sensitive photolabile protecting groups and photocleavable linkers, as well as develop methods for the selective photo-derivatization and release of thiol moieties in various substrates. Photolabile protecting groups allow for the spatiotemporal control of substrate activation, as well as for 'reagentless' deprotection. Release of active compounds using light at the red edge of the visible spectrum extends the utility of the 'caging' technique in biology as it minimizes photo-damage to cells and might be useful for experiments in mammalian tissues.. This project aims to provide organic, biological, and medicinal chemists with new tools to control activity of caged compounds in time and in space, with potentially broad application. For example, the selective and reversible derivatization of native or genetically engineered cysteine residues in proteins may allow for the remote control of their activity. Reversible immobilization can be useful for modification or repair of sensor arrays. This project will provide undergraduate and graduate students, including those from groups historically underrepresented in the sciences, with interdisciplinary training at the interface of synthetic and physical organic chemistry, with elements of photochemistry, biochemistry, and material science.
有了这个奖项,化学部的化学合成计划资助教授弗拉基米尔Popik的化学系在格鲁吉亚大学设计和合成新型紫外线和近红外敏感的光不稳定的保护基团和光可裂解的连接器,以及开发方法的选择性光衍生化和释放硫醇部分在各种基板。光不稳定的保护基团允许时空控制底物活化,以及“无试剂”脱保护。使用可见光谱红边的光释放活性化合物扩展了生物学中“笼”技术的实用性,因为它最大限度地减少了对细胞的光损伤,并可能用于哺乳动物组织的实验。该项目旨在为有机,生物和药物化学家提供新的工具来控制笼状化合物在时间和空间上的活性,具有潜在的广泛应用。 例如,蛋白质中天然或遗传工程改造的半胱氨酸残基的选择性和可逆衍生化可以允许远程控制其活性。可逆固定可用于传感器阵列的修饰或修复。该项目将为本科生和研究生,包括那些来自历史上在科学中代表性不足的群体的学生,提供合成和物理有机化学界面的跨学科培训,以及光化学,生物化学和材料科学的元素。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vladimir Popik其他文献
Beilstein Journal of Organic Chemistry Beilstein Journal of Organic Chemistry Beilstein Journal of Organic Chemistry Colchitaxel, a Coupled Compound Made from Microtubule Inhibitors Colchicine and Paclitaxel
贝尔斯坦有机化学杂志 贝尔斯坦有机化学杂志 贝尔斯坦有机化学杂志 秋水仙素,一种由微管抑制剂秋水仙碱和紫杉醇制成的偶联化合物
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
K. Bombuwala;T. Kinstle;Vladimir Popik;S. Uppal;J. Olesen;J. Viña;C. A. Heckman;Email Karunananda;Com;Edu;James B Edu;Jose;A. Heckman - 通讯作者:
A. Heckman
Vladimir Popik的其他文献
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{{ truncateString('Vladimir Popik', 18)}}的其他基金
Cyclopropenone-based Platform for Light-directed Drug Delivery, Photo-medicine, and Bio-imaging
基于环丙烯酮的光定向药物输送、光医学和生物成像平台
- 批准号:
1900464 - 财政年份:2019
- 资助金额:
$ 42.6万 - 项目类别:
Standard Grant
Quinone methide - based strategies for reversible modification, protection, and ligation of biological substrates and polymers
基于醌甲基化物的生物底物和聚合物的可逆修饰、保护和连接策略
- 批准号:
1565646 - 财政年份:2016
- 资助金额:
$ 42.6万 - 项目类别:
Continuing Grant
Development of Photolabile Protecting Groups and Photochromic Systems Based on Intramolecular Excited State Proton Transfer
基于分子内激发态质子转移的光不稳定保护基团和光致变色体系的开发
- 批准号:
0842590 - 财政年份:2009
- 资助金额:
$ 42.6万 - 项目类别:
Continuing Grant
CAREER: Towards Space- and Time- resolved Generation of p-Benzyne Diradical: Development of Photoswitchable Analogs of Natural Enediyne Antibiotics
职业:实现对苯炔双自由基的空间和时间分辨生成:天然烯二炔抗生素的光开关类似物的开发
- 批准号:
0449478 - 财政年份:2005
- 资助金额:
$ 42.6万 - 项目类别:
Continuing Grant
CAREER: Towards Space- and Time- resolved Generation of p-Benzyne Diradical: Development of Photoswitchable Analogs of Natural Enediyne Antibiotics
职业:实现对苯炔双自由基的空间和时间分辨生成:天然烯二炔抗生素的光开关类似物的开发
- 批准号:
0631210 - 财政年份:2005
- 资助金额:
$ 42.6万 - 项目类别:
Continuing Grant
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