Sensitivity and Selectivity Enhancement Strategies for Silicon Photonic Biosensor Arrays

硅光子生物传感器阵列的灵敏度和选择性增强策略

• 批准号: 1214081
• 负责人: Ryan Bailey
• 金额: $ 40万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1214081&HistoricalAwards=false
• 关键词: Sensitivity; Selectivity; Enhancement; Strategies; Silicon

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professor Ryan Bailey and his group at University of Illinois at Urbana-Champaign are developing a scalable and cost effective chemical and biochemical analysis platform based upon chip-integrated silicon optical devices. The intellectual merit of this scientific program lies in the application of novel mechanisms for detecting very small numbers of analyte molecules from within highly complex sample matrices. Fundamental advances in these approaches, which center around the monitoring of dynamic, rather than steady-state, sensor responses, will broadly facilitate the ultrasensitive detection of chemical and biomolecular species in a range of demanding analytical applications, including food quality assurance, homeland security, forensics, medical diagnostics, and environmental monitoring.Beyond the scientific goals of this project, which offer significant potential benefits to society, this award also supports a rich interdisciplinary training environment for graduate and undergraduate students. In particular, students from diverse backgrounds benefit from hands-on education, mentoring, and active research training towards future careers as measurement scientists. Students are also actively encouraged and supported to participate in a multitude of local educational outreach opportunities that work to improve science education at the primary, high school, and undergraduate levels. Dissemination of program successes to both technical (scientific publications and conferences) and non-technical (popular press and educational outreach) audiences helps maximize the broader impacts that this research has in meeting our country's current and emerging scientific and educational needs.

在化学系化学测量和成像项目的支持下，伊利诺伊大学厄巴纳-香槟分校的Ryan Bailey教授及其团队正在开发一种基于芯片集成硅光学器件的可扩展且具有成本效益的化学和生化分析平台。这一科学计划的智力价值在于应用新的机制，从高度复杂的样品基质中检测非常少量的分析物分子。这些方法的基本进展主要集中在动态而非稳态传感器响应的监测上，将广泛促进化学和生物分子物种的超灵敏检测，用于一系列要求苛刻的分析应用，包括食品质量保证、国土安全、法医学、医学诊断和环境监测。该奖项还为研究生和本科生提供了丰富的跨学科培训环境。特别是，来自不同背景的学生受益于实践教育，指导和积极的研究培训，以实现未来的职业生涯作为测量科学家。学生还积极鼓励和支持参与众多的地方教育推广机会，努力提高小学，高中和本科水平的科学教育。向技术（科学出版物和会议）和非技术（大众媒体和教育宣传）受众传播计划成功有助于最大限度地扩大这项研究在满足我国当前和新兴科学和教育需求方面的广泛影响。