Role of autophagy in degradation of endoplasmic reticulum (ER)-localised protein aggregates

自噬在内质网 (ER) 定位蛋白聚集体降解中的作用

• 批准号: LX0989187
• 负责人: Em/Prof Ian Dawes
• 金额: $ 5.85万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage - International
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-03-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LX0989187
• 关键词: Role; autophagy; degradation; endoplasmic; reticulum

This study will provide a new understanding of protein aggregate accumulation in the endoplasmic reticulum (ER), a phenomenon that occurs in aging cells and protein conformational diseases, and under stress conditions and during secretory protein overexpression. This information will inform strategies to prevent the onset of protein conformational diseases and help identify targets for pharmaceutical intervention. In addition, a powerful model system for studies of ER protein aggregation will be established, high-level training in biochemistry and morphometry will be provided, and an international collaboration of the highest calibre will be initiated.

该研究将对内质网（ER）蛋白质聚集积累提供新的认识，这是一种在细胞老化和蛋白质构象疾病中发生的现象，以及在应激条件下和分泌性蛋白质过表达过程中发生的现象。这一信息将为预防蛋白质构象疾病发作的策略提供信息，并有助于确定药物干预的目标。此外，将建立一个研究内质网蛋白聚集的强大模型系统，提供生物化学和形态计量学方面的高水平培训，并启动最高水平的国际合作。