Cellular Responses to Oxidative Damage: Cell Aging

细胞对氧化损伤的反应：细胞衰老

• 批准号: DP0344964
• 负责人: Em/Prof Ian Dawes
• 金额: $ 81.94万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-07-01 至 2009-12-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0344964
• 关键词: Cellular; Responses; Oxidative; Damage; Cell

The aim of this project is to identify the mechanisms by which oxidative stress and free radical damage cause cell aging. This work will make a significant contribution to our understanding of the aging process in cells by identifying the major reactive oxygen species that contribute to cell aging, which defence systems and antioxidants provide the greatest degree of protection, what damage accumulates as cells age and which genetic systems are activated as during the process.

该项目的目的是确定氧化应激和自由基损伤导致细胞衰老的机制。 这项工作将通过确定导致细胞衰老的主要活性氧物质，哪些防御系统和抗氧化剂提供最大程度的保护，随着细胞衰老积累的损害以及在此过程中激活的遗传系统，为我们了解细胞衰老过程做出重大贡献。